[ 3H]TCP binding sites in Alzheimer's disease

Quantitative autoradiography was used to determine the density and distribution of [ 3H]1-[1-(2-thienyl)-cyclohexyl]piperidine ([ 3H]TCP) binding sites in human hippocampal tissue sections from control and Alzheimer's disease patients. Some Alzheimer's cases showed no changes in binding si...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience letters 1987-01, Vol.73 (2), p.197-200
Hauptverfasser:	Monaghan, D.T., Geddes, J.W., Yao, D., Chung, C., Cotman, C.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	[formula omitted] (NMDA) Alzheimer Disease - metabolism Alzheimer's disease Autoradiography Binding Sites Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Excitatory amino acid Hippocampus Hippocampus - metabolism Humans Medical sciences Neurology Phencyclidine Phencyclidine - analogs & derivatives Phencyclidine - metabolism Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Quantitative autoradiography was used to determine the density and distribution of [ 3H]1-[1-(2-thienyl)-cyclohexyl]piperidine ([ 3H]TCP) binding sites in human hippocampal tissue sections from control and Alzheimer's disease patients. Some Alzheimer's cases showed no changes in binding site density while other cases showed substantial declines in the CA 1 region. [ 3H]TCP binding in the CA 1 region from Alzheimer's patients was reduced an average of 40% while the other hippocampal regions were unaffected. It is proposed that the loss of [ 3H]TCP sites in the hippocampal CA 1 region of certain Alzheimer's cases is associated with the greater cell loss observed in cases of severe Alzheimer's disease.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(87)90017-6