A T-cell receptor γ/CD3 complex found on cloned functional lymphocytes

Cloned blood lymphocytes that do not express the α- and β-chains of the T-cell receptor show MHC-unrestricted cytotoxicity. These cells carry the γ-protein, disulphide-linked either to another molecule or to itself, and associated with the CD3 complex. These observations may help to solve the myster...

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Veröffentlicht in:	Nature (London) 1987-02, Vol.325 (6106), p.683-688
Hauptverfasser:	Borst, Jannie, van de Griend, René J., van Oostveen, Johan W., Ang, Siew-Lan, Melief, Cornelis J., Seidman, J. G., Bolhuis, Reinder L. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Differentiation, T-Lymphocyte Antigens, Surface - genetics Antigens, Surface - immunology Clone Cells - immunology Cytotoxicity, Immunologic Disulfides Gene Expression Regulation Humanities and Social Sciences Humans Immunologic Deficiency Syndromes - immunology Macromolecular Substances multidisciplinary Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology RNA, Messenger - genetics Science Science (multidisciplinary) T-Lymphocytes - immunology
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Zusammenfassung:	Cloned blood lymphocytes that do not express the α- and β-chains of the T-cell receptor show MHC-unrestricted cytotoxicity. These cells carry the γ-protein, disulphide-linked either to another molecule or to itself, and associated with the CD3 complex. These observations may help to solve the mystery posed by the discovery of the γ gene.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/325683a0