Studies on the Inhibitory Effects of Caffeoylquinic Acids on Monocyte Migration and Superoxide Ion Production

Studies on the Inhibitory Effects of Caffeoylquinic Acids on Monocyte Migration and Superoxide Ion Production

Three caffeoylquinic acids, isolated from the Peruvian plants Tessaria integrifolia and Mikania cordifolia that are used medicinally as anti-inflammatory agents, were tested for their activities on monocyte migration and superoxide anion production. 3,5-Di-O-caffeoylquinic and 4,5-di-O-caffeoylquini...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 1995-05, Vol.58 (5), p.639-646
Hauptverfasser: Peluso, Gianfranco, De Feo, Vincenzo, De Simone, Francesco, Bresciano, Elio, Vuotto, Maria Luisa
Format: Artikel
Sprache:eng
Schlagworte:
ALLOMONE
ALLOMONES
ALOMONAS
Amino Acid Sequence
ANION
ANIONES
ANIONS
ANTIINFLAMMATOIRE
ANTIINFLAMMATORY AGENTS
ANTINFLAMATORIOS
Cells, Cultured
CHEMICAL COMPOSITION
Chemotaxis, Leukocyte - drug effects
CHLOROGENIC ACID
COMPOSICION QUIMICA
COMPOSITAE
COMPOSITION CHIMIQUE
DOSAGE EFFECTS
FEUILLE
HOJAS
Humans
LEAVES
MIKANIA
Mikania cordifolia
Molecular Sequence Data
MONOCITOS
MONOCYTE
MONOCYTES
Monocytes - cytology
Monocytes - drug effects
Monocytes - metabolism
N-Formylmethionine Leucyl-Phenylalanine - pharmacology
PEROU
PERU
Plants, Medicinal - cytology
Quinic Acid - analogs & derivatives
Quinic Acid - isolation & purification
Quinic Acid - pharmacology
superoxide anion production
Superoxides - metabolism
TESSARIA INTEGRIFOLIA
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Zusammenfassung:Three caffeoylquinic acids, isolated from the Peruvian plants Tessaria integrifolia and Mikania cordifolia that are used medicinally as anti-inflammatory agents, were tested for their activities on monocyte migration and superoxide anion production. 3,5-Di-O-caffeoylquinic and 4,5-di-O-caffeoylquinic acids exhibited an appreciable anti-inflammatory activity in vitro, while the tricaffeoyl derivative was inactive.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50119a001