SSRIs in anxious-agitated depression: a post-hoc analysis of 279 patients

A post-hoc analysis of nine controlled antidepressant trials examined the intensity of the initial anxiety and agitation of depressed patients improved by SSRIs compared with depressed patients improved by norepinephrine (NK) reuptake inhibitors, mixed NE/serotonin reuptake inhibitors and placebo. W...

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Veröffentlicht in:	International clinical psychopharmacology 1995-03, Vol.10 (1), p.51-51
Hauptverfasser:	Filteau, M J, Baruch, P, Lapierre, Y D, Bakish, D, Blanchard, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Uptake Inhibitors - therapeutic use Adult Aged Anxiety Disorders - complications Anxiety Disorders - drug therapy Anxiety Disorders - psychology Biological and medical sciences Depressive Disorder - complications Depressive Disorder - drug therapy Depressive Disorder - psychology Double-Blind Method Female Humans Male Medical sciences Middle Aged Neuropharmacology Norepinephrine - physiology Pharmacology. Drug treatments Psychiatric Status Rating Scales Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Serotonin Uptake Inhibitors - therapeutic use
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Zusammenfassung:	A post-hoc analysis of nine controlled antidepressant trials examined the intensity of the initial anxiety and agitation of depressed patients improved by SSRIs compared with depressed patients improved by norepinephrine (NK) reuptake inhibitors, mixed NE/serotonin reuptake inhibitors and placebo. We report that SSKI responders were more anxious-agitated than NE reuptake inhibitor responders, suggesting a preferential efficacy of SSRIs in agitated depression.
ISSN:	0268-1315 1473-5857
DOI:	10.1097/00004850-199503000-00007