Progressive systemic sclerosis: autoimmune arteriopathy

In a case of progressive systemic sclerosis (PSS), widespread deposition of IgM was found in the media and internal elastic lamina of small muscular arteries. IgA and C3 were also found in some vessels. Antibody eluted from the kidney bound to smooth muscle and elastica of small arteries. These find...

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Veröffentlicht in:	The Lancet (British edition) 1987-02, Vol.1 (8531), p.480-482
Hauptverfasser:	EVANS, D. J, CASHMAN, S. J, WALPORT, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Arteries - immunology Autoantibodies - analysis Biological and medical sciences Complement C3 - analysis Female Humans Immunoglobulin A - analysis Immunoglobulin M - analysis Kidney - blood supply Kidney - immunology Medical sciences Muscles - blood supply Muscles - immunology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Scleroderma, Systemic - immunology Skin - immunology
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Zusammenfassung:	In a case of progressive systemic sclerosis (PSS), widespread deposition of IgM was found in the media and internal elastic lamina of small muscular arteries. IgA and C3 were also found in some vessels. Antibody eluted from the kidney bound to smooth muscle and elastica of small arteries. These findings suggest that PSS is a vasculopathy which is mediated by complement-fixing antibodies.
ISSN:	0140-6736 1474-547X