The in vitro screening of methylated 4-oxypiperidine compounds for inhibition of protein synthesis in a rabbit reticulocyte cell-free translation system

A variety of methylated 4-oxypiperidine derivatives were tested for their ability to inhibit protein synthesis in vitro. A direct correlation was found between the extent of methylation of these compounds and their inhibitory activity in a rabbit reticulocyte lysate cell-free translation system.

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Bibliographische Detailangaben
Veröffentlicht in:	Cell biology and toxicology 1986-09, Vol.2 (3), p.337-340
Hauptverfasser:	Kuznetsov, D A, Zavijalov, N V, Kelman, G J, Govorkov, A V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclic N-Oxides - pharmacology In Vitro Techniques Methylation Protein Biosynthesis - drug effects Protein Synthesis Inhibitors - pharmacology Rabbits Spin Labels
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Beschreibung
Zusammenfassung:	A variety of methylated 4-oxypiperidine derivatives were tested for their ability to inhibit protein synthesis in vitro. A direct correlation was found between the extent of methylation of these compounds and their inhibitory activity in a rabbit reticulocyte lysate cell-free translation system.
ISSN:	0742-2091 1573-6822
DOI:	10.1007/BF00121849