The rat-pull test procedure: A method for assessing the strength of rats

A novel method for the measurement of rat strength is described. The method makes use of a rat's natural inclination to move forcibly and rapidly toward an enclosed, darkened compartment. Acrylamide (200.0 mg/kg, IP), gentamicin (30.0 mg/kg, IP), d-tubocurarine (0.1 mg/kg, IP), and diazepam (3....

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1995-04, Vol.50 (4), p.517-519
Hauptverfasser:	Giardina, William J., Wismer, Carol T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamide Acrylamides - pharmacology Animals Biological and medical sciences Diazepam - pharmacology Drug toxicity and drugs side effects treatment Ergometry - methods Ergometry - veterinary Evaluation Studies as Topic Gentamicins - pharmacology Grip strength Male Medical sciences Muscle Contraction - drug effects Muscle dysfunction Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Reproducibility of Results Sensitivity and Specificity Strength Toxicity: nervous system and muscle Tubocurarine - pharmacology
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Zusammenfassung:	A novel method for the measurement of rat strength is described. The method makes use of a rat's natural inclination to move forcibly and rapidly toward an enclosed, darkened compartment. Acrylamide (200.0 mg/kg, IP), gentamicin (30.0 mg/kg, IP), d-tubocurarine (0.1 mg/kg, IP), and diazepam (3.0, 10.0, and 30.0 mg/kg, PO) significantly decreased strength. The rat-pull test procedure provides a sensitive, reliable, and valid method for the measurement of strength in rats.
ISSN:	0091-3057 1873-5177
DOI:	10.1016/0091-3057(94)00327-0