Ganglioglioma with neurofibrillary tangles (NFTs) : neoplastic NFTs share antigenic determinants with NFTs of Alzheimer's disease

A cerebral ganglioglioma contained abundant neurofibrillary tangles (NFTs) of the paired helical filament (PHF) type. The NFTs in the tumor were argyrophilic and Congo red and thioflavin-S positive. Immunohistochemically, the NFTs were reactive with antibodies to phosphorylated neurofilament protein...

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Veröffentlicht in:	Acta neuropathologica 1995-05, Vol.89 (5), p.451-453
Hauptverfasser:	SOFFER, D, UMANSKY, F, GOLDMAN, J. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alzheimer Disease - metabolism Alzheimer Disease - pathology Biological and medical sciences Brain Neoplasms - metabolism Brain Neoplasms - pathology Epitopes - analysis Ganglioglioma - metabolism Ganglioglioma - pathology Humans Immunohistochemistry Male Medical sciences Neurofibrillary Tangles - metabolism Neurofibrillary Tangles - pathology Neurofilament Proteins - metabolism Neurology Staining and Labeling tau Proteins - metabolism Tumors of the nervous system. Phacomatoses Ubiquitins - metabolism
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Zusammenfassung:	A cerebral ganglioglioma contained abundant neurofibrillary tangles (NFTs) of the paired helical filament (PHF) type. The NFTs in the tumor were argyrophilic and Congo red and thioflavin-S positive. Immunohistochemically, the NFTs were reactive with antibodies to phosphorylated neurofilament protein, PHF/tau and ubiquitin. The demonstration in the neoplasm of abnormally phosphorylated and ubiquitinated cytoskeletal components, similar in morphology and in immunoreactivity to those seen in NFTs of Alzheimer's disease, suggest that similar pathogenetic mechanisms may operate in both conditions.
ISSN:	0001-6322 1432-0533
DOI:	10.1007/BF00307651