DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat
DNA extracted from regional brain samples of hypoxic/ischemic neonatal rats showed internucleosomal cleavage indicative of apoptosis. Cells containing cleaved DNA were identified by in situ labelling in the cortex, hippocampus, striatum and thalamus of the ipsilateral hemisphere. When the effects of...
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| Veröffentlicht in: | Brain research 1995-04, Vol.676 (2), p.398-403 |
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| container_title | Brain research |
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| creator | Hill, Irene E. MacManus, John P. Rasquinha, Ingrid Tuor, Ursula I. |
| description | DNA extracted from regional brain samples of hypoxic/ischemic neonatal rats showed internucleosomal cleavage indicative of apoptosis. Cells containing cleaved DNA were identified by in situ labelling in the cortex, hippocampus, striatum and thalamus of the ipsilateral hemisphere. When the effects of increasing the length of the hypoxia were examined, increases were seen in the amount of internucleosomally cleaved DNA and in the number of labelled cells. |
| doi_str_mv | 10.1016/0006-8993(95)00145-G |
| format | Article |
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Cells containing cleaved DNA were identified by in situ labelling in the cortex, hippocampus, striatum and thalamus of the ipsilateral hemisphere. When the effects of increasing the length of the hypoxia were examined, increases were seen in the amount of internucleosomally cleaved DNA and in the number of labelled cells.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(95)00145-G</identifier><identifier>PMID: 7614012</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Animals, Newborn ; Apoptosis ; Apoptosis - genetics ; Biological and medical sciences ; Brain Ischemia - complications ; Brain Ischemia - metabolism ; Brain Ischemia - pathology ; Cell death ; DNA Damage ; Functional Laterality - physiology ; Hypoxia, Brain - complications ; Hypoxia, Brain - metabolism ; Hypoxia, Brain - pathology ; Hypoxia-ischemia ; Internucleosomal cleavage ; Medical sciences ; Neonatal ; Neurology ; Neurons - pathology ; Rats ; Rats, Wistar ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Brain research, 1995-04, Vol.676 (2), p.398-403</ispartof><rights>1995 Elsevier Science B.V. All rights reserved</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-5749e7a6cccae89f7c7195b627c853de81a9376fabdf5ece094f1e22b7a9b7943</citedby><cites>FETCH-LOGICAL-c534t-5749e7a6cccae89f7c7195b627c853de81a9376fabdf5ece094f1e22b7a9b7943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(95)00145-G$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3475630$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7614012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hill, Irene E.</creatorcontrib><creatorcontrib>MacManus, John P.</creatorcontrib><creatorcontrib>Rasquinha, Ingrid</creatorcontrib><creatorcontrib>Tuor, Ursula I.</creatorcontrib><title>DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>DNA extracted from regional brain samples of hypoxic/ischemic neonatal rats showed internucleosomal cleavage indicative of apoptosis. Cells containing cleaved DNA were identified by in situ labelling in the cortex, hippocampus, striatum and thalamus of the ipsilateral hemisphere. When the effects of increasing the length of the hypoxia were examined, increases were seen in the amount of internucleosomally cleaved DNA and in the number of labelled cells.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Apoptosis</subject><subject>Apoptosis - genetics</subject><subject>Biological and medical sciences</subject><subject>Brain Ischemia - complications</subject><subject>Brain Ischemia - metabolism</subject><subject>Brain Ischemia - pathology</subject><subject>Cell death</subject><subject>DNA Damage</subject><subject>Functional Laterality - physiology</subject><subject>Hypoxia, Brain - complications</subject><subject>Hypoxia, Brain - metabolism</subject><subject>Hypoxia, Brain - pathology</subject><subject>Hypoxia-ischemia</subject><subject>Internucleosomal cleavage</subject><subject>Medical sciences</subject><subject>Neonatal</subject><subject>Neurology</subject><subject>Neurons - pathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EKtvCPwApB4TgELDj2I4vlapSFqQKLnC2Js6ka-TEwfYW-u9x2NUe4eSx5punp_cIecHoO0aZfE8plXWnNX-jxVtKWSvq7SOyYZ1qatm09DHZnJCn5DylH-XLuaZn5ExJ1lLWbIj_8OWqGiPcTThnyC7MlZsHZ8t4j1UYK1jCkkNyqRqD9-GXm--q_ew8ZIzgK4sR-3XYPSzht4PaJbvDyUGRqfIOqxnDDLkAEfIz8mQEn_D58b0g3z_efLv-VN9-3X6-vrqtreBtroVqNSqQ1lrATo_KKqZFLxtlO8EH7BhoruQI_TAKtEh1OzJsml6B7pVu-QV5fdBdYvi5x5TNVGyh91Dc7JNRimslFP0vyGTHmFCsgO0BtDGkFHE0S3QTxAfDqFnbMGvUZo3aaGH-tmG25ezlUX_fTzicjo7xl_2r4x6SBV96mK1LJ4y3Ski-2rw8YFhCu3cYTbIOZ4uDi2izGYL7t48_miyn4A</recordid><startdate>19950410</startdate><enddate>19950410</enddate><creator>Hill, Irene E.</creator><creator>MacManus, John P.</creator><creator>Rasquinha, Ingrid</creator><creator>Tuor, Ursula I.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19950410</creationdate><title>DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat</title><author>Hill, Irene E. ; MacManus, John P. ; Rasquinha, Ingrid ; Tuor, Ursula I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-5749e7a6cccae89f7c7195b627c853de81a9376fabdf5ece094f1e22b7a9b7943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Apoptosis</topic><topic>Apoptosis - genetics</topic><topic>Biological and medical sciences</topic><topic>Brain Ischemia - complications</topic><topic>Brain Ischemia - metabolism</topic><topic>Brain Ischemia - pathology</topic><topic>Cell death</topic><topic>DNA Damage</topic><topic>Functional Laterality - physiology</topic><topic>Hypoxia, Brain - complications</topic><topic>Hypoxia, Brain - metabolism</topic><topic>Hypoxia, Brain - pathology</topic><topic>Hypoxia-ischemia</topic><topic>Internucleosomal cleavage</topic><topic>Medical sciences</topic><topic>Neonatal</topic><topic>Neurology</topic><topic>Neurons - pathology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hill, Irene E.</creatorcontrib><creatorcontrib>MacManus, John P.</creatorcontrib><creatorcontrib>Rasquinha, Ingrid</creatorcontrib><creatorcontrib>Tuor, Ursula I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hill, Irene E.</au><au>MacManus, John P.</au><au>Rasquinha, Ingrid</au><au>Tuor, Ursula I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1995-04-10</date><risdate>1995</risdate><volume>676</volume><issue>2</issue><spage>398</spage><epage>403</epage><pages>398-403</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>DNA extracted from regional brain samples of hypoxic/ischemic neonatal rats showed internucleosomal cleavage indicative of apoptosis. Cells containing cleaved DNA were identified by in situ labelling in the cortex, hippocampus, striatum and thalamus of the ipsilateral hemisphere. When the effects of increasing the length of the hypoxia were examined, increases were seen in the amount of internucleosomally cleaved DNA and in the number of labelled cells.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>7614012</pmid><doi>10.1016/0006-8993(95)00145-G</doi><tpages>6</tpages></addata></record> |
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| ispartof | Brain research, 1995-04, Vol.676 (2), p.398-403 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Animals, Newborn Apoptosis Apoptosis - genetics Biological and medical sciences Brain Ischemia - complications Brain Ischemia - metabolism Brain Ischemia - pathology Cell death DNA Damage Functional Laterality - physiology Hypoxia, Brain - complications Hypoxia, Brain - metabolism Hypoxia, Brain - pathology Hypoxia-ischemia Internucleosomal cleavage Medical sciences Neonatal Neurology Neurons - pathology Rats Rats, Wistar Vascular diseases and vascular malformations of the nervous system |
| title | DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat |
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