DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat

DNA extracted from regional brain samples of hypoxic/ischemic neonatal rats showed internucleosomal cleavage indicative of apoptosis. Cells containing cleaved DNA were identified by in situ labelling in the cortex, hippocampus, striatum and thalamus of the ipsilateral hemisphere. When the effects of...

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Veröffentlicht in:	Brain research 1995-04, Vol.676 (2), p.398-403
Hauptverfasser:	Hill, Irene E., MacManus, John P., Rasquinha, Ingrid, Tuor, Ursula I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis Apoptosis - genetics Biological and medical sciences Brain Ischemia - complications Brain Ischemia - metabolism Brain Ischemia - pathology Cell death DNA Damage Functional Laterality - physiology Hypoxia, Brain - complications Hypoxia, Brain - metabolism Hypoxia, Brain - pathology Hypoxia-ischemia Internucleosomal cleavage Medical sciences Neonatal Neurology Neurons - pathology Rats Rats, Wistar Vascular diseases and vascular malformations of the nervous system
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Zusammenfassung:	DNA extracted from regional brain samples of hypoxic/ischemic neonatal rats showed internucleosomal cleavage indicative of apoptosis. Cells containing cleaved DNA were identified by in situ labelling in the cortex, hippocampus, striatum and thalamus of the ipsilateral hemisphere. When the effects of increasing the length of the hypoxia were examined, increases were seen in the amount of internucleosomally cleaved DNA and in the number of labelled cells.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(95)00145-G