Endothelin-1 focally constricts pulmonary veins in rats
Serum endothelin levels increase during sepsis, ischemia, reperfusion, pulmonary operations, and systemic hypertension after surgery. Despite extensive study, the site and extent of action of endothelin on the pulmonary microcirculation are not well established. To assess the effect of endothelin on...
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| creator | Aharinejad, S Schraufnagel, D. E Miksovsky, A Larson, E. K Marks, S. C., Jr |
| description | Serum endothelin levels increase during sepsis, ischemia, reperfusion, pulmonary operations, and systemic hypertension after surgery. Despite extensive study, the site and extent of action of endothelin on the pulmonary microcirculation are not well established. To assess the effect of endothelin on the pulmonary vasculature, especially the veins, the circulation of the lung was cast with methyl methacrylate 10 minutes after endothelin-1 was given intravenously to rats. Endothelin-1, at concentrations of 0.1, 1.0, and 10.0 μg/kg of body weight, increased the mean systemic arterial blood pressure 8%, 7%, and 17% (
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| doi_str_mv | 10.1016/S0022-5223(05)80020-0 |
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p<0.01) and mean pulmonary arterial blood pressure 15%, 28%, and 53%, respectively (
p<0.01). The proportional increases in the pulmonary pressures were greater than those of the systemic pressures (
p<0.01). Scanning electron microscopy of cast blood vessels showed more contraction of the veins than the arteries. For doses of 0, 0.1, 1.0, and 10.0 μg/kg, the respective focal contraction of small veins was 6.7% (±4.4), 15.4% (±9.1), 23.3% (±10.1), and 14.4% (±9.0) of the vessel diameter (
p<0.01). In addition, the diameters of capillaries increased (
p<0.01) and the capillary interspaces decreased (
p<0.01) after endothelin administration, but not in a linear dose-dependent manner. The dose of endothelin correlated with the change in the mean systemic (
r=0.82,
p<0.01) and the mean pulmonary (
r=0.80,
p< 0.01) blood pressures. The mean pulmonary pressure change correlated with the focal venous contraction on the casts (
r=0.35,
p<0.01), capillary diameter (
r=0.64,
p<0.01), and capillary interspece distance (
r=-0.34,
p< 0.01). The venous contraction was related to the capillary diameter (
r=0.26,
p<0.01). The most notable effect of endothelin-1 in rat pulmonary microcirculation is focal constriction of small veins. Because this effect may lead to pulmonary edema, endothelin antagnists may be of benefit in a variety of clinical situations.]]></description><identifier>ISSN: 0022-5223</identifier><identifier>EISSN: 1097-685X</identifier><identifier>DOI: 10.1016/S0022-5223(05)80020-0</identifier><identifier>PMID: 7609538</identifier><identifier>CODEN: JTCSAQ</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Analysis of Variance ; Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Blood vessels and receptors ; Capillaries - drug effects ; Capillaries - ultrastructure ; Endothelins - pharmacology ; Fundamental and applied biological sciences. Psychology ; Male ; Microcirculation - drug effects ; Microscopy, Electron, Scanning ; Pulmonary Alveoli - blood supply ; Pulmonary Alveoli - ultrastructure ; Pulmonary Artery - drug effects ; Pulmonary Artery - ultrastructure ; Pulmonary Veins - drug effects ; Pulmonary Veins - ultrastructure ; Rats ; Rats, Inbred WKY ; Regression Analysis ; Vasoconstriction - drug effects ; Vertebrates: cardiovascular system</subject><ispartof>The Journal of thoracic and cardiovascular surgery, 1995-07, Vol.110 (1), p.148-156</ispartof><rights>1995 Mosby-Year Book, Inc.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-26371db8d1d6080e04afd2037f828dd4e95151b6de08df15b4abfd30ef4d5a653</citedby><cites>FETCH-LOGICAL-c468t-26371db8d1d6080e04afd2037f828dd4e95151b6de08df15b4abfd30ef4d5a653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-5223(05)80020-0$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3595674$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7609538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aharinejad, S</creatorcontrib><creatorcontrib>Schraufnagel, D. E</creatorcontrib><creatorcontrib>Miksovsky, A</creatorcontrib><creatorcontrib>Larson, E. K</creatorcontrib><creatorcontrib>Marks, S. C., Jr</creatorcontrib><title>Endothelin-1 focally constricts pulmonary veins in rats</title><title>The Journal of thoracic and cardiovascular surgery</title><addtitle>J Thorac Cardiovasc Surg</addtitle><description><![CDATA[Serum endothelin levels increase during sepsis, ischemia, reperfusion, pulmonary operations, and systemic hypertension after surgery. Despite extensive study, the site and extent of action of endothelin on the pulmonary microcirculation are not well established. To assess the effect of endothelin on the pulmonary vasculature, especially the veins, the circulation of the lung was cast with methyl methacrylate 10 minutes after endothelin-1 was given intravenously to rats. Endothelin-1, at concentrations of 0.1, 1.0, and 10.0 μg/kg of body weight, increased the mean systemic arterial blood pressure 8%, 7%, and 17% (
p<0.01) and mean pulmonary arterial blood pressure 15%, 28%, and 53%, respectively (
p<0.01). The proportional increases in the pulmonary pressures were greater than those of the systemic pressures (
p<0.01). Scanning electron microscopy of cast blood vessels showed more contraction of the veins than the arteries. For doses of 0, 0.1, 1.0, and 10.0 μg/kg, the respective focal contraction of small veins was 6.7% (±4.4), 15.4% (±9.1), 23.3% (±10.1), and 14.4% (±9.0) of the vessel diameter (
p<0.01). In addition, the diameters of capillaries increased (
p<0.01) and the capillary interspaces decreased (
p<0.01) after endothelin administration, but not in a linear dose-dependent manner. The dose of endothelin correlated with the change in the mean systemic (
r=0.82,
p<0.01) and the mean pulmonary (
r=0.80,
p< 0.01) blood pressures. The mean pulmonary pressure change correlated with the focal venous contraction on the casts (
r=0.35,
p<0.01), capillary diameter (
r=0.64,
p<0.01), and capillary interspece distance (
r=-0.34,
p< 0.01). The venous contraction was related to the capillary diameter (
r=0.26,
p<0.01). The most notable effect of endothelin-1 in rat pulmonary microcirculation is focal constriction of small veins. Because this effect may lead to pulmonary edema, endothelin antagnists may be of benefit in a variety of clinical situations.]]></description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Blood vessels and receptors</subject><subject>Capillaries - drug effects</subject><subject>Capillaries - ultrastructure</subject><subject>Endothelins - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Microcirculation - drug effects</subject><subject>Microscopy, Electron, Scanning</subject><subject>Pulmonary Alveoli - blood supply</subject><subject>Pulmonary Alveoli - ultrastructure</subject><subject>Pulmonary Artery - drug effects</subject><subject>Pulmonary Artery - ultrastructure</subject><subject>Pulmonary Veins - drug effects</subject><subject>Pulmonary Veins - ultrastructure</subject><subject>Rats</subject><subject>Rats, Inbred WKY</subject><subject>Regression Analysis</subject><subject>Vasoconstriction - drug effects</subject><subject>Vertebrates: cardiovascular system</subject><issn>0022-5223</issn><issn>1097-685X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EKkvhJ1TKAVE4pIyT-CMnhKryIVXqAZC4WY49Zl0lzuLJtuq_x_uhvXKyRvO841cPYxccrjhw-fEHQNPUomna9yA-6DJBDc_YikOvaqnF7-dsdUJesldE9wCggPdn7ExJ6EWrV0zdJD8vaxxjqnkVZmfH8alyc6IlR7dQtdmO05xsfqoeMCaqYqqyXeg1exHsSPjm-J6zX19ufl5_q2_vvn6__nxbu07qpW5kq7gftOdeggaEzgbfQKuCbrT3HfaCCz5Ij6B94GLo7BB8Cxg6L6wU7Tl7d7i7yfPfLdJipkgOx9EmnLdklGp7BXtQHECXZ6KMwWxynEpvw8HshJm9MLOzYUCYvTADJXdx_GA7TOhPqaOhsn973FsqckK2yUU6Ya3ohVRdwS4P2Dr-WT_GjIamorIc5eZ-ccR3LQzvdgc_HUgs2h4iZkMuYnLoS8otxs_xP5X_AapslBw</recordid><startdate>19950701</startdate><enddate>19950701</enddate><creator>Aharinejad, S</creator><creator>Schraufnagel, D. E</creator><creator>Miksovsky, A</creator><creator>Larson, E. K</creator><creator>Marks, S. C., Jr</creator><general>Mosby, Inc</general><general>AATS/WTSA</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950701</creationdate><title>Endothelin-1 focally constricts pulmonary veins in rats</title><author>Aharinejad, S ; Schraufnagel, D. E ; Miksovsky, A ; Larson, E. K ; Marks, S. C., Jr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-26371db8d1d6080e04afd2037f828dd4e95151b6de08df15b4abfd30ef4d5a653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Blood vessels and receptors</topic><topic>Capillaries - drug effects</topic><topic>Capillaries - ultrastructure</topic><topic>Endothelins - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Microcirculation - drug effects</topic><topic>Microscopy, Electron, Scanning</topic><topic>Pulmonary Alveoli - blood supply</topic><topic>Pulmonary Alveoli - ultrastructure</topic><topic>Pulmonary Artery - drug effects</topic><topic>Pulmonary Artery - ultrastructure</topic><topic>Pulmonary Veins - drug effects</topic><topic>Pulmonary Veins - ultrastructure</topic><topic>Rats</topic><topic>Rats, Inbred WKY</topic><topic>Regression Analysis</topic><topic>Vasoconstriction - drug effects</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aharinejad, S</creatorcontrib><creatorcontrib>Schraufnagel, D. E</creatorcontrib><creatorcontrib>Miksovsky, A</creatorcontrib><creatorcontrib>Larson, E. K</creatorcontrib><creatorcontrib>Marks, S. C., Jr</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aharinejad, S</au><au>Schraufnagel, D. E</au><au>Miksovsky, A</au><au>Larson, E. K</au><au>Marks, S. C., Jr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelin-1 focally constricts pulmonary veins in rats</atitle><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle><addtitle>J Thorac Cardiovasc Surg</addtitle><date>1995-07-01</date><risdate>1995</risdate><volume>110</volume><issue>1</issue><spage>148</spage><epage>156</epage><pages>148-156</pages><issn>0022-5223</issn><eissn>1097-685X</eissn><coden>JTCSAQ</coden><abstract><![CDATA[Serum endothelin levels increase during sepsis, ischemia, reperfusion, pulmonary operations, and systemic hypertension after surgery. Despite extensive study, the site and extent of action of endothelin on the pulmonary microcirculation are not well established. To assess the effect of endothelin on the pulmonary vasculature, especially the veins, the circulation of the lung was cast with methyl methacrylate 10 minutes after endothelin-1 was given intravenously to rats. Endothelin-1, at concentrations of 0.1, 1.0, and 10.0 μg/kg of body weight, increased the mean systemic arterial blood pressure 8%, 7%, and 17% (
p<0.01) and mean pulmonary arterial blood pressure 15%, 28%, and 53%, respectively (
p<0.01). The proportional increases in the pulmonary pressures were greater than those of the systemic pressures (
p<0.01). Scanning electron microscopy of cast blood vessels showed more contraction of the veins than the arteries. For doses of 0, 0.1, 1.0, and 10.0 μg/kg, the respective focal contraction of small veins was 6.7% (±4.4), 15.4% (±9.1), 23.3% (±10.1), and 14.4% (±9.0) of the vessel diameter (
p<0.01). In addition, the diameters of capillaries increased (
p<0.01) and the capillary interspaces decreased (
p<0.01) after endothelin administration, but not in a linear dose-dependent manner. The dose of endothelin correlated with the change in the mean systemic (
r=0.82,
p<0.01) and the mean pulmonary (
r=0.80,
p< 0.01) blood pressures. The mean pulmonary pressure change correlated with the focal venous contraction on the casts (
r=0.35,
p<0.01), capillary diameter (
r=0.64,
p<0.01), and capillary interspece distance (
r=-0.34,
p< 0.01). The venous contraction was related to the capillary diameter (
r=0.26,
p<0.01). The most notable effect of endothelin-1 in rat pulmonary microcirculation is focal constriction of small veins. Because this effect may lead to pulmonary edema, endothelin antagnists may be of benefit in a variety of clinical situations.]]></abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>7609538</pmid><doi>10.1016/S0022-5223(05)80020-0</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Analysis of Variance Animals Biological and medical sciences Blood Pressure - drug effects Blood vessels and receptors Capillaries - drug effects Capillaries - ultrastructure Endothelins - pharmacology Fundamental and applied biological sciences. Psychology Male Microcirculation - drug effects Microscopy, Electron, Scanning Pulmonary Alveoli - blood supply Pulmonary Alveoli - ultrastructure Pulmonary Artery - drug effects Pulmonary Artery - ultrastructure Pulmonary Veins - drug effects Pulmonary Veins - ultrastructure Rats Rats, Inbred WKY Regression Analysis Vasoconstriction - drug effects Vertebrates: cardiovascular system |
| title | Endothelin-1 focally constricts pulmonary veins in rats |
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