Endothelin-1 focally constricts pulmonary veins in rats

Serum endothelin levels increase during sepsis, ischemia, reperfusion, pulmonary operations, and systemic hypertension after surgery. Despite extensive study, the site and extent of action of endothelin on the pulmonary microcirculation are not well established. To assess the effect of endothelin on...

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Veröffentlicht in:The Journal of thoracic and cardiovascular surgery 1995-07, Vol.110 (1), p.148-156
Hauptverfasser: Aharinejad, S, Schraufnagel, D. E, Miksovsky, A, Larson, E. K, Marks, S. C., Jr
Format: Artikel
Sprache:eng
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Zusammenfassung:Serum endothelin levels increase during sepsis, ischemia, reperfusion, pulmonary operations, and systemic hypertension after surgery. Despite extensive study, the site and extent of action of endothelin on the pulmonary microcirculation are not well established. To assess the effect of endothelin on the pulmonary vasculature, especially the veins, the circulation of the lung was cast with methyl methacrylate 10 minutes after endothelin-1 was given intravenously to rats. Endothelin-1, at concentrations of 0.1, 1.0, and 10.0 μg/kg of body weight, increased the mean systemic arterial blood pressure 8%, 7%, and 17% ( p
ISSN:0022-5223
1097-685X
DOI:10.1016/S0022-5223(05)80020-0