Reduction of suicidal thoughts with paroxetine in comparison with reference antidepressants and placebo

Reduction of suicidal thoughts with paroxetine in comparison with reference antidepressants and placebo

In order to determine whether paroxetine was associated with any increase in suicidal thoughts or acts all controlled studies of paroxetine were examined in a series of metanalyses. Paroxetine showed an advantage in reducing suicidal thoughts in all analyses compared with placebo. On the MADRS there...

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Veröffentlicht in:European neuropsychopharmacology 1995-03, Vol.5 (1), p.5-13
Hauptverfasser: Montgomery, S.A., Dunner, D.L., Dunbar, G.C.
Format: Artikel
Sprache:eng
Schlagworte:
Antidepressive Agents - pharmacology
Female
Humans
Imipramine - pharmacology
Male
Paroxetine
Paroxetine - pharmacology
Placebo
Psychiatric Status Rating Scales
Suicidal thoughts
Suicidality
Suicide
Suicide, Attempted - prevention & control
Time Factors
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Zusammenfassung:In order to determine whether paroxetine was associated with any increase in suicidal thoughts or acts all controlled studies of paroxetine were examined in a series of metanalyses. Paroxetine showed an advantage in reducing suicidal thoughts in all analyses compared with placebo. On the MADRS there was a significant advantage compared with active controls at weeks 1, 3, 4 and 6 ( P
ISSN:0924-977X
1873-7862
DOI:10.1016/0924-977X(94)00131-T