Synthesis and presence of atrial natriuretic factor in rat ventricle

Rat heart ventricles contained immunoreactive atrial natriuretic factor (irANF) and mRNA for ANF. The size of ANF mRNA in the ventricle was identical with that of the atria. High performance gel filtration chromatography showed that 84% of ventricular irANF elutes at a position corresponding to the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 1987-01, Vol.142 (2), p.483-488
Hauptverfasser:	Takayanagi, Ryoichi, Imada, Teruaki, Inagami, Tadashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied sciences Atrial Natriuretic Factor - analysis Atrial Natriuretic Factor - biosynthesis Atrial Natriuretic Factor - genetics Exact sciences and technology Heart Ventricles Male Molecular Weight Myocardium - analysis Myocardium - metabolism Other techniques and industries Rats Rats, Inbred SHR Rats, Inbred WKY RNA, Messenger - analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Rat heart ventricles contained immunoreactive atrial natriuretic factor (irANF) and mRNA for ANF. The size of ANF mRNA in the ventricle was identical with that of the atria. High performance gel filtration chromatography showed that 84% of ventricular irANF elutes at a position corresponding to the low molecular weight form of ANF (99–126) and 16% of irANF elutes at a position corresponding to the precursor form of ANF. The irANF content of the ventricles of spontaneously hypertensive rats was 3 times as much as that of Wistar Kyoto rats. These results suggest that ventricle synthesizes ANF in response to hypertension and processes in a manner different from that in atria.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(87)90300-7