o, p′-DDT (1,1,1-trichloro-2 ( p-chlorophenyl) 2-( o-chlorophenyl) ethane is a purely estrogenic agonist in the rat uterus in vivo and in vitro

In order to define the class of estrogenic compounds to which o-p'-DDT pertains, the authors compared its action on the rat uterus to that exerted by 17 beta -estradiol. This included time-course studies on o-p'-DDT induced changes in uterine wet weight and RNA, protein and glycogen contents together with measurement of eosinophils counts and cGMP content. The effect of o-p'-DDT on two uterine responses that can be obtained in vitro with estradiol was evaluated. The authors also tested the effect of pretreatments with o-p'-DDT on further uterine responsiveness to 17 beta -estradiol. Treatments with the less estrogenic derivative, p,p'-DDT were included for comparison.