A heritable fragile 12q24.13 segregating in a family with the fragile X chromosome

A heritable fragile 12q24.13 segregating in a family with the fragile X chromosome

A fragile site on chromosome 12, at 12q24.13, was found in the lymphocytes of two members of a family during the study for detection of a fragile X chromosome. The site was found to be heritable and folate-sensitive, and it fulfills all four criteria for a fragile site. It thus can now be confirmed...

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Veröffentlicht in:Human genetics 1987, Vol.75 (1), p.4-6
Hauptverfasser: AMAROSE, A. P, HUTTENLOCHER, P. R, SPRUDZS, R. M, LAITSCH, T. J, PETTENATI, M. J
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Biological and medical sciences
Chromosome Banding
Chromosome Fragile Sites
Chromosome Fragility
Chromosome fragility (bloom syndrome, ataxia telangiectasia, fanconi anemia, x-linked mental retardation...)
Chromosomes, Human, Pair 12
Female
Humans
Karyotyping
Male
Medical genetics
Medical sciences
X Chromosome
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Zusammenfassung:A fragile site on chromosome 12, at 12q24.13, was found in the lymphocytes of two members of a family during the study for detection of a fragile X chromosome. The site was found to be heritable and folate-sensitive, and it fulfills all four criteria for a fragile site. It thus can now be confirmed as the heritable fragile site FRA12C.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00273829