Zinc and Alzheimer's Disease
The accuracy of a claim that zinc ions enhances aggregation of beta-amyloid protein, associated with Alzheimer's disease, is disputed. The original paper is said to include evidence that copper and mercury also contribute to the aggregation. A reply is included.
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1995-06, Vol.268 (5219), p.1920-1923 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1923 |
|---|---|
| container_issue | 5219 |
| container_start_page | 1920 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 268 |
| creator | Fitzgerald, D. James Maggio, John E. Esler, William P. Stimson, Evelyn R. Jennings, Joan M. Ghilardi, Joseph R. Mantyh, Patrick W. Bush, Ashley I. Moir, Robert D. Rosenkranz, Kari M. Tanzi, Rudolph E. |
| description | The accuracy of a claim that zinc ions enhances aggregation of beta-amyloid protein, associated with Alzheimer's disease, is disputed. The original paper is said to include evidence that copper and mercury also contribute to the aggregation. A reply is included. |
| doi_str_mv | 10.1126/science.7604268 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_77381018</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A17253822</galeid><jstor_id>2887870</jstor_id><sourcerecordid>A17253822</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-5bd188dc8de2a9c82131008952237764cc45805e9bf06b304bf1c593bae346dc3</originalsourceid><addsrcrecordid>eNqN0s9r2zAUB3AxNro063mXDnJae6jbJ8m25GOadWkhLIe2O-wiZPk5U_GPTLKh7V8_hZiWQA5BB4G-Hz0evEfIVwqXlLL0yhuLjcFLkULMUvmBjChkSZQx4B_JCICnkQSRfCbH3j8BhCzjR-Ro4CNy-sc2ZqKbYjKtXv-irdGd-ckP61F7_EI-lbryeDLcY_L48-ZhdhstlvO72XQRmQR4FyV5QaUsjCyQ6cxIRjkFkFnCGBcijY2JEwkJZnkJac4hzktqQh-5Rh6nheFj8n1bd-3afz36TtXWG6wq3WDbeyUElxSoPASKUHIDL7ZwpStUtinbzmmzwgadrtoGSxuep1SwhMvQ5ZhEe3g4BdbW7PPnOz6QDp-7le69V3f3vw6my98H0-v5oVTOFzv0Yh81bVXhClUY5Gy5w6-23LjWe4elWjtba_eiKKjNyqlh5dSwQ-HHt2EofV5j8ebf89Nt_uS71r3FTEohBfD_oaTUWw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77373468</pqid></control><display><type>article</type><title>Zinc and Alzheimer's Disease</title><source>MEDLINE</source><source>Science Magazine</source><source>JSTOR Archive Collection A-Z Listing</source><creator>Fitzgerald, D. James ; Maggio, John E. ; Esler, William P. ; Stimson, Evelyn R. ; Jennings, Joan M. ; Ghilardi, Joseph R. ; Mantyh, Patrick W. ; Bush, Ashley I. ; Moir, Robert D. ; Rosenkranz, Kari M. ; Tanzi, Rudolph E.</creator><creatorcontrib>Fitzgerald, D. James ; Maggio, John E. ; Esler, William P. ; Stimson, Evelyn R. ; Jennings, Joan M. ; Ghilardi, Joseph R. ; Mantyh, Patrick W. ; Bush, Ashley I. ; Moir, Robert D. ; Rosenkranz, Kari M. ; Tanzi, Rudolph E.</creatorcontrib><description>The accuracy of a claim that zinc ions enhances aggregation of beta-amyloid protein, associated with Alzheimer's disease, is disputed. The original paper is said to include evidence that copper and mercury also contribute to the aggregation. A reply is included.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.7604268</identifier><identifier>PMID: 7604268</identifier><language>eng</language><publisher>United States: American Society for the Advancement of Science</publisher><subject>Aggregation ; Alzheimer Disease - metabolism ; Alzheimer's disease ; Amyloid beta-Peptides - metabolism ; Amyloids ; Awards ; Centrifugation ; Cerebrospinal fluid ; Copper - cerebrospinal fluid ; Copper - metabolism ; Health aspects ; Humans ; Iron - cerebrospinal fluid ; Iron - metabolism ; Medical schools ; Metal ions ; Optical density ; Protein Binding ; Rats ; Silicon - cerebrospinal fluid ; Silicon - metabolism ; Technical Comments ; Zinc ; Zinc (Nutrient) ; Zinc - cerebrospinal fluid ; Zinc - metabolism ; Zinc - pharmacology ; Zinc in the body</subject><ispartof>Science (American Association for the Advancement of Science), 1995-06, Vol.268 (5219), p.1920-1923</ispartof><rights>Copyright 1995 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1995 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1995 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-5bd188dc8de2a9c82131008952237764cc45805e9bf06b304bf1c593bae346dc3</citedby><cites>FETCH-LOGICAL-c503t-5bd188dc8de2a9c82131008952237764cc45805e9bf06b304bf1c593bae346dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2887870$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2887870$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7604268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fitzgerald, D. James</creatorcontrib><creatorcontrib>Maggio, John E.</creatorcontrib><creatorcontrib>Esler, William P.</creatorcontrib><creatorcontrib>Stimson, Evelyn R.</creatorcontrib><creatorcontrib>Jennings, Joan M.</creatorcontrib><creatorcontrib>Ghilardi, Joseph R.</creatorcontrib><creatorcontrib>Mantyh, Patrick W.</creatorcontrib><creatorcontrib>Bush, Ashley I.</creatorcontrib><creatorcontrib>Moir, Robert D.</creatorcontrib><creatorcontrib>Rosenkranz, Kari M.</creatorcontrib><creatorcontrib>Tanzi, Rudolph E.</creatorcontrib><title>Zinc and Alzheimer's Disease</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The accuracy of a claim that zinc ions enhances aggregation of beta-amyloid protein, associated with Alzheimer's disease, is disputed. The original paper is said to include evidence that copper and mercury also contribute to the aggregation. A reply is included.</description><subject>Aggregation</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer's disease</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Amyloids</subject><subject>Awards</subject><subject>Centrifugation</subject><subject>Cerebrospinal fluid</subject><subject>Copper - cerebrospinal fluid</subject><subject>Copper - metabolism</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Iron - cerebrospinal fluid</subject><subject>Iron - metabolism</subject><subject>Medical schools</subject><subject>Metal ions</subject><subject>Optical density</subject><subject>Protein Binding</subject><subject>Rats</subject><subject>Silicon - cerebrospinal fluid</subject><subject>Silicon - metabolism</subject><subject>Technical Comments</subject><subject>Zinc</subject><subject>Zinc (Nutrient)</subject><subject>Zinc - cerebrospinal fluid</subject><subject>Zinc - metabolism</subject><subject>Zinc - pharmacology</subject><subject>Zinc in the body</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s9r2zAUB3AxNro063mXDnJae6jbJ8m25GOadWkhLIe2O-wiZPk5U_GPTLKh7V8_hZiWQA5BB4G-Hz0evEfIVwqXlLL0yhuLjcFLkULMUvmBjChkSZQx4B_JCICnkQSRfCbH3j8BhCzjR-Ro4CNy-sc2ZqKbYjKtXv-irdGd-ckP61F7_EI-lbryeDLcY_L48-ZhdhstlvO72XQRmQR4FyV5QaUsjCyQ6cxIRjkFkFnCGBcijY2JEwkJZnkJac4hzktqQh-5Rh6nheFj8n1bd-3afz36TtXWG6wq3WDbeyUElxSoPASKUHIDL7ZwpStUtinbzmmzwgadrtoGSxuep1SwhMvQ5ZhEe3g4BdbW7PPnOz6QDp-7le69V3f3vw6my98H0-v5oVTOFzv0Yh81bVXhClUY5Gy5w6-23LjWe4elWjtba_eiKKjNyqlh5dSwQ-HHt2EofV5j8ebf89Nt_uS71r3FTEohBfD_oaTUWw</recordid><startdate>19950630</startdate><enddate>19950630</enddate><creator>Fitzgerald, D. James</creator><creator>Maggio, John E.</creator><creator>Esler, William P.</creator><creator>Stimson, Evelyn R.</creator><creator>Jennings, Joan M.</creator><creator>Ghilardi, Joseph R.</creator><creator>Mantyh, Patrick W.</creator><creator>Bush, Ashley I.</creator><creator>Moir, Robert D.</creator><creator>Rosenkranz, Kari M.</creator><creator>Tanzi, Rudolph E.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7X8</scope></search><sort><creationdate>19950630</creationdate><title>Zinc and Alzheimer's Disease</title><author>Fitzgerald, D. James ; Maggio, John E. ; Esler, William P. ; Stimson, Evelyn R. ; Jennings, Joan M. ; Ghilardi, Joseph R. ; Mantyh, Patrick W. ; Bush, Ashley I. ; Moir, Robert D. ; Rosenkranz, Kari M. ; Tanzi, Rudolph E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-5bd188dc8de2a9c82131008952237764cc45805e9bf06b304bf1c593bae346dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Aggregation</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer's disease</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Amyloids</topic><topic>Awards</topic><topic>Centrifugation</topic><topic>Cerebrospinal fluid</topic><topic>Copper - cerebrospinal fluid</topic><topic>Copper - metabolism</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Iron - cerebrospinal fluid</topic><topic>Iron - metabolism</topic><topic>Medical schools</topic><topic>Metal ions</topic><topic>Optical density</topic><topic>Protein Binding</topic><topic>Rats</topic><topic>Silicon - cerebrospinal fluid</topic><topic>Silicon - metabolism</topic><topic>Technical Comments</topic><topic>Zinc</topic><topic>Zinc (Nutrient)</topic><topic>Zinc - cerebrospinal fluid</topic><topic>Zinc - metabolism</topic><topic>Zinc - pharmacology</topic><topic>Zinc in the body</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fitzgerald, D. James</creatorcontrib><creatorcontrib>Maggio, John E.</creatorcontrib><creatorcontrib>Esler, William P.</creatorcontrib><creatorcontrib>Stimson, Evelyn R.</creatorcontrib><creatorcontrib>Jennings, Joan M.</creatorcontrib><creatorcontrib>Ghilardi, Joseph R.</creatorcontrib><creatorcontrib>Mantyh, Patrick W.</creatorcontrib><creatorcontrib>Bush, Ashley I.</creatorcontrib><creatorcontrib>Moir, Robert D.</creatorcontrib><creatorcontrib>Rosenkranz, Kari M.</creatorcontrib><creatorcontrib>Tanzi, Rudolph E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fitzgerald, D. James</au><au>Maggio, John E.</au><au>Esler, William P.</au><au>Stimson, Evelyn R.</au><au>Jennings, Joan M.</au><au>Ghilardi, Joseph R.</au><au>Mantyh, Patrick W.</au><au>Bush, Ashley I.</au><au>Moir, Robert D.</au><au>Rosenkranz, Kari M.</au><au>Tanzi, Rudolph E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zinc and Alzheimer's Disease</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1995-06-30</date><risdate>1995</risdate><volume>268</volume><issue>5219</issue><spage>1920</spage><epage>1923</epage><pages>1920-1923</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>The accuracy of a claim that zinc ions enhances aggregation of beta-amyloid protein, associated with Alzheimer's disease, is disputed. The original paper is said to include evidence that copper and mercury also contribute to the aggregation. A reply is included.</abstract><cop>United States</cop><pub>American Society for the Advancement of Science</pub><pmid>7604268</pmid><doi>10.1126/science.7604268</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1995-06, Vol.268 (5219), p.1920-1923 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77381018 |
| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | Aggregation Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloids Awards Centrifugation Cerebrospinal fluid Copper - cerebrospinal fluid Copper - metabolism Health aspects Humans Iron - cerebrospinal fluid Iron - metabolism Medical schools Metal ions Optical density Protein Binding Rats Silicon - cerebrospinal fluid Silicon - metabolism Technical Comments Zinc Zinc (Nutrient) Zinc - cerebrospinal fluid Zinc - metabolism Zinc - pharmacology Zinc in the body |
| title | Zinc and Alzheimer's Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T08%3A18%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Zinc%20and%20Alzheimer's%20Disease&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Fitzgerald,%20D.%20James&rft.date=1995-06-30&rft.volume=268&rft.issue=5219&rft.spage=1920&rft.epage=1923&rft.pages=1920-1923&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.7604268&rft_dat=%3Cgale_proqu%3EA17253822%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77373468&rft_id=info:pmid/7604268&rft_galeid=A17253822&rft_jstor_id=2887870&rfr_iscdi=true |