Zinc and Alzheimer's Disease

The accuracy of a claim that zinc ions enhances aggregation of beta-amyloid protein, associated with Alzheimer's disease, is disputed. The original paper is said to include evidence that copper and mercury also contribute to the aggregation. A reply is included.

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Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1995-06, Vol.268 (5219), p.1920-1923
Hauptverfasser:	Fitzgerald, D. James, Maggio, John E., Esler, William P., Stimson, Evelyn R., Jennings, Joan M., Ghilardi, Joseph R., Mantyh, Patrick W., Bush, Ashley I., Moir, Robert D., Rosenkranz, Kari M., Tanzi, Rudolph E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregation Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloids Awards Centrifugation Cerebrospinal fluid Copper - cerebrospinal fluid Copper - metabolism Health aspects Humans Iron - cerebrospinal fluid Iron - metabolism Medical schools Metal ions Optical density Protein Binding Rats Silicon - cerebrospinal fluid Silicon - metabolism Technical Comments Zinc Zinc (Nutrient) Zinc - cerebrospinal fluid Zinc - metabolism Zinc - pharmacology Zinc in the body
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Beschreibung
Zusammenfassung:	The accuracy of a claim that zinc ions enhances aggregation of beta-amyloid protein, associated with Alzheimer's disease, is disputed. The original paper is said to include evidence that copper and mercury also contribute to the aggregation. A reply is included.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.7604268