Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease
Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the $\beta $ peptide of brain amyloid from Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids, includ...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1987-02, Vol.235 (4791), p.877-880 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Goldgaber, Dmitry Lerman, Michael I. McBride, O. Wesley Saffiotti, Umberto Gajdusek, D. Carleton |
| description | Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the $\beta $ peptide of brain amyloid from Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids, including the known amino acid sequence of this polypeptide. The 3.5-kilobase messenger RNA was detected in mammalian brains and human thymus. The gene is highly conserved in evolution and has been mapped to human chromosome 21. |
| doi_str_mv | 10.1126/science.3810169 |
| format | Article |
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Wesley ; Saffiotti, Umberto ; Gajdusek, D. Carleton</creator><creatorcontrib>Goldgaber, Dmitry ; Lerman, Michael I. ; McBride, O. Wesley ; Saffiotti, Umberto ; Gajdusek, D. Carleton ; National Institutes of Health, Bethesda, MD</creatorcontrib><description>Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the $\beta $ peptide of brain amyloid from Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids, including the known amino acid sequence of this polypeptide. The 3.5-kilobase messenger RNA was detected in mammalian brains and human thymus. The gene is highly conserved in evolution and has been mapped to human chromosome 21.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3810169</identifier><identifier>PMID: 3810169</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>550200 - Biochemistry ; 550900 - Pathology ; Alzheimer Disease - genetics ; Alzheimer's disease ; Alzheimers disease ; AMINO ACID SEQUENCE ; Amino acids ; amyloid ; Amyloid - genetics ; Amyloids ; ANIMALS ; BASIC BIOLOGICAL SCIENCES ; Biological and medical sciences ; BODY ; BRAIN ; CENTRAL NERVOUS SYSTEM ; chromosome 21 ; CHROMOSOMES ; Chromosomes, Human, Pair 21 ; CLONING ; Cloning, Molecular ; Complementary DNA ; DATA ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; DISEASES ; DNA ; DNA - genetics ; DNA SEQUENCING ; DNA-CLONING ; EXPERIMENTAL DATA ; gene mapping ; GENES ; Genetic aspects ; GENETIC MAPPING ; Genetics ; Humans ; Hybridity ; INFORMATION ; LYMPHATIC SYSTEM ; MAMMALS ; MAN ; MAPPING ; Medical research ; Medical sciences ; MESSENGER-RNA ; MOLECULAR STRUCTURE ; NERVOUS SYSTEM ; NERVOUS SYSTEM DISEASES ; Neurological disorders ; Neurology ; Neurons ; NUCLEIC ACIDS ; NUMERICAL DATA ; ORGANIC COMPOUNDS ; ORGANS ; PATHOGENESIS ; PEPTIDES ; POLYPEPTIDES ; PRIMATES ; Protein Conformation ; PROTEINS ; RNA ; RNA, Messenger - genetics ; Solubility ; STRUCTURAL CHEMICAL ANALYSIS ; THYMUS ; Transcription, Genetic ; VERTEBRATES</subject><ispartof>Science (American Association for the Advancement of Science), 1987-02, Vol.235 (4791), p.877-880</ispartof><rights>Copyright 1987 The American Association for the Advancement of Science</rights><rights>1987 INIST-CNRS</rights><rights>COPYRIGHT 1987 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1987 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Feb 20, 1987</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c822t-7d29e068e8a9d00ce33018a3c76c81316c043e6ac9707ab8a1a4784c1d9656683</citedby><cites>FETCH-LOGICAL-c822t-7d29e068e8a9d00ce33018a3c76c81316c043e6ac9707ab8a1a4784c1d9656683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1698512$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1698512$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,881,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8088943$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3810169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6518558$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Goldgaber, Dmitry</creatorcontrib><creatorcontrib>Lerman, Michael I.</creatorcontrib><creatorcontrib>McBride, O. Wesley</creatorcontrib><creatorcontrib>Saffiotti, Umberto</creatorcontrib><creatorcontrib>Gajdusek, D. Carleton</creatorcontrib><creatorcontrib>National Institutes of Health, Bethesda, MD</creatorcontrib><title>Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the $\beta $ peptide of brain amyloid from Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids, including the known amino acid sequence of this polypeptide. The 3.5-kilobase messenger RNA was detected in mammalian brains and human thymus. The gene is highly conserved in evolution and has been mapped to human chromosome 21.</description><subject>550200 - Biochemistry</subject><subject>550900 - Pathology</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer's disease</subject><subject>Alzheimers disease</subject><subject>AMINO ACID SEQUENCE</subject><subject>Amino acids</subject><subject>amyloid</subject><subject>Amyloid - genetics</subject><subject>Amyloids</subject><subject>ANIMALS</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>Biological and medical sciences</subject><subject>BODY</subject><subject>BRAIN</subject><subject>CENTRAL NERVOUS SYSTEM</subject><subject>chromosome 21</subject><subject>CHROMOSOMES</subject><subject>Chromosomes, Human, Pair 21</subject><subject>CLONING</subject><subject>Cloning, Molecular</subject><subject>Complementary DNA</subject><subject>DATA</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>DISEASES</subject><subject>DNA</subject><subject>DNA - genetics</subject><subject>DNA SEQUENCING</subject><subject>DNA-CLONING</subject><subject>EXPERIMENTAL DATA</subject><subject>gene mapping</subject><subject>GENES</subject><subject>Genetic aspects</subject><subject>GENETIC MAPPING</subject><subject>Genetics</subject><subject>Humans</subject><subject>Hybridity</subject><subject>INFORMATION</subject><subject>LYMPHATIC SYSTEM</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>MAPPING</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>MESSENGER-RNA</subject><subject>MOLECULAR STRUCTURE</subject><subject>NERVOUS SYSTEM</subject><subject>NERVOUS SYSTEM DISEASES</subject><subject>Neurological disorders</subject><subject>Neurology</subject><subject>Neurons</subject><subject>NUCLEIC ACIDS</subject><subject>NUMERICAL DATA</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANS</subject><subject>PATHOGENESIS</subject><subject>PEPTIDES</subject><subject>POLYPEPTIDES</subject><subject>PRIMATES</subject><subject>Protein Conformation</subject><subject>PROTEINS</subject><subject>RNA</subject><subject>RNA, Messenger - genetics</subject><subject>Solubility</subject><subject>STRUCTURAL CHEMICAL ANALYSIS</subject><subject>THYMUS</subject><subject>Transcription, Genetic</subject><subject>VERTEBRATES</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN089r2zAUB3AzNros23mXDcwY66FLK1mWLB3dtMsKoTnsx1Wo8nOiYEut5MDav34K8ZIOAgk-CPw-lq339UuS9xidY5yxi6ANWA3nhGOEmXiRDDASdCQyRF4mA4QIG3FU0NfJmxCWCMWaICfJSc8HCYwXyivdgTdPqjPOpspW6XjhXeuCa1WTTp1Wzb-iq1OV6qvbMr222lXGztNLr4xNy_axcaZag7J5WoBpwZ-G9MoEUAHeJq9q1QR416_D5Ne365_j76PpbHIzLqcjzbOsGxVVJgAxDlyJCiENhCDMFdEF0xwTzDTKCTClRYEKdccVVnnBc40rwShjnAyTT5t9XeiMjL3pQC-0sxZ0JxnFnNI1-rJB9949rCB0sjVBQ9MoC24VZFGQghYsPwgJRSL28TDMMOZF_LyDEOciJoPp7iBbuHQrb2Pv4maEEprFgIfJ2QbNVQPS2Np1Mco5WPCqcRZqE2-XORMIoyzqr3t0vCpojd7DT__jUXTwp5urVQjy5sftsXL2-1h5OTlS8sn0uTzbJ7VrGpiDjL_XePZcX2y09i4ED7W896ZV_lFiJNcDJfuBkv2ExCc-9kms7lqotn5X_9zXVYiDUntltQlbxhHnIl8n_2HDlqFzfvdWJjjFGfkLHLwrrQ</recordid><startdate>19870220</startdate><enddate>19870220</enddate><creator>Goldgaber, Dmitry</creator><creator>Lerman, Michael I.</creator><creator>McBride, O. 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Wesley ; Saffiotti, Umberto ; Gajdusek, D. Carleton</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c822t-7d29e068e8a9d00ce33018a3c76c81316c043e6ac9707ab8a1a4784c1d9656683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>550200 - Biochemistry</topic><topic>550900 - Pathology</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer's disease</topic><topic>Alzheimers disease</topic><topic>AMINO ACID SEQUENCE</topic><topic>Amino acids</topic><topic>amyloid</topic><topic>Amyloid - genetics</topic><topic>Amyloids</topic><topic>ANIMALS</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>Biological and medical sciences</topic><topic>BODY</topic><topic>BRAIN</topic><topic>CENTRAL NERVOUS SYSTEM</topic><topic>chromosome 21</topic><topic>CHROMOSOMES</topic><topic>Chromosomes, Human, Pair 21</topic><topic>CLONING</topic><topic>Cloning, Molecular</topic><topic>Complementary DNA</topic><topic>DATA</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>DISEASES</topic><topic>DNA</topic><topic>DNA - genetics</topic><topic>DNA SEQUENCING</topic><topic>DNA-CLONING</topic><topic>EXPERIMENTAL DATA</topic><topic>gene mapping</topic><topic>GENES</topic><topic>Genetic aspects</topic><topic>GENETIC MAPPING</topic><topic>Genetics</topic><topic>Humans</topic><topic>Hybridity</topic><topic>INFORMATION</topic><topic>LYMPHATIC SYSTEM</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>MAPPING</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>MESSENGER-RNA</topic><topic>MOLECULAR STRUCTURE</topic><topic>NERVOUS SYSTEM</topic><topic>NERVOUS SYSTEM DISEASES</topic><topic>Neurological disorders</topic><topic>Neurology</topic><topic>Neurons</topic><topic>NUCLEIC ACIDS</topic><topic>NUMERICAL DATA</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANS</topic><topic>PATHOGENESIS</topic><topic>PEPTIDES</topic><topic>POLYPEPTIDES</topic><topic>PRIMATES</topic><topic>Protein Conformation</topic><topic>PROTEINS</topic><topic>RNA</topic><topic>RNA, Messenger - genetics</topic><topic>Solubility</topic><topic>STRUCTURAL CHEMICAL ANALYSIS</topic><topic>THYMUS</topic><topic>Transcription, Genetic</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goldgaber, Dmitry</creatorcontrib><creatorcontrib>Lerman, Michael I.</creatorcontrib><creatorcontrib>McBride, O. 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Wesley</au><au>Saffiotti, Umberto</au><au>Gajdusek, D. Carleton</au><aucorp>National Institutes of Health, Bethesda, MD</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1987-02-20</date><risdate>1987</risdate><volume>235</volume><issue>4791</issue><spage>877</spage><epage>880</epage><pages>877-880</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the $\beta $ peptide of brain amyloid from Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids, including the known amino acid sequence of this polypeptide. The 3.5-kilobase messenger RNA was detected in mammalian brains and human thymus. The gene is highly conserved in evolution and has been mapped to human chromosome 21.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3810169</pmid><doi>10.1126/science.3810169</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1987-02, Vol.235 (4791), p.877-880 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77375764 |
| source | Jstor Complete Legacy; MEDLINE; Science Magazine |
| subjects | 550200 - Biochemistry 550900 - Pathology Alzheimer Disease - genetics Alzheimer's disease Alzheimers disease AMINO ACID SEQUENCE Amino acids amyloid Amyloid - genetics Amyloids ANIMALS BASIC BIOLOGICAL SCIENCES Biological and medical sciences BODY BRAIN CENTRAL NERVOUS SYSTEM chromosome 21 CHROMOSOMES Chromosomes, Human, Pair 21 CLONING Cloning, Molecular Complementary DNA DATA Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DISEASES DNA DNA - genetics DNA SEQUENCING DNA-CLONING EXPERIMENTAL DATA gene mapping GENES Genetic aspects GENETIC MAPPING Genetics Humans Hybridity INFORMATION LYMPHATIC SYSTEM MAMMALS MAN MAPPING Medical research Medical sciences MESSENGER-RNA MOLECULAR STRUCTURE NERVOUS SYSTEM NERVOUS SYSTEM DISEASES Neurological disorders Neurology Neurons NUCLEIC ACIDS NUMERICAL DATA ORGANIC COMPOUNDS ORGANS PATHOGENESIS PEPTIDES POLYPEPTIDES PRIMATES Protein Conformation PROTEINS RNA RNA, Messenger - genetics Solubility STRUCTURAL CHEMICAL ANALYSIS THYMUS Transcription, Genetic VERTEBRATES |
| title | Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease |
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