Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the $\beta $ peptide of brain amyloid from Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids, includ...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1987-02, Vol.235 (4791), p.877-880
Hauptverfasser:	Goldgaber, Dmitry, Lerman, Michael I., McBride, O. Wesley, Saffiotti, Umberto, Gajdusek, D. Carleton
Format:	Artikel
Sprache:	eng
Schlagworte:	550200 - Biochemistry 550900 - Pathology Alzheimer Disease - genetics Alzheimer's disease Alzheimers disease AMINO ACID SEQUENCE Amino acids amyloid Amyloid - genetics Amyloids ANIMALS BASIC BIOLOGICAL SCIENCES Biological and medical sciences BODY BRAIN CENTRAL NERVOUS SYSTEM chromosome 21 CHROMOSOMES Chromosomes, Human, Pair 21 CLONING Cloning, Molecular Complementary DNA DATA Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DISEASES DNA DNA - genetics DNA SEQUENCING DNA-CLONING EXPERIMENTAL DATA gene mapping GENES Genetic aspects GENETIC MAPPING Genetics Humans Hybridity INFORMATION LYMPHATIC SYSTEM MAMMALS MAN MAPPING Medical research Medical sciences MESSENGER-RNA MOLECULAR STRUCTURE NERVOUS SYSTEM NERVOUS SYSTEM DISEASES Neurological disorders Neurology Neurons NUCLEIC ACIDS NUMERICAL DATA ORGANIC COMPOUNDS ORGANS PATHOGENESIS PEPTIDES POLYPEPTIDES PRIMATES Protein Conformation PROTEINS RNA RNA, Messenger - genetics Solubility STRUCTURAL CHEMICAL ANALYSIS THYMUS Transcription, Genetic VERTEBRATES
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Zusammenfassung:	Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the $\beta $ peptide of brain amyloid from Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids, including the known amino acid sequence of this polypeptide. The 3.5-kilobase messenger RNA was detected in mammalian brains and human thymus. The gene is highly conserved in evolution and has been mapped to human chromosome 21.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.3810169