Flow cytometric analysis of nuclear DNA content in oral leukoplakia: relation to clinicopathologic findings

DNA ploidy of 50 biopsy specimens of oral leukoplakia was investigated by flow cytometry, and the results were compared with the clinicopathologic appearances. The aneuploidy rate of the leukoplakias was 17/50 (34%), and the mean DNA index (DI) of the aneuploid lesions was 1.22, with a range from 0....

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Veröffentlicht in:International journal of oral and maxillofacial surgery 1995-02, Vol.24 (1), p.44-47
Hauptverfasser: Saito, Tohru, Yamashita, Tomomi, Notani, Ken-ichi, Fukuda, Hiroshi, Mizuno, Shigetaka, Shindon, Masanobu, Amemlya, Akira
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Sprache:eng
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Zusammenfassung:DNA ploidy of 50 biopsy specimens of oral leukoplakia was investigated by flow cytometry, and the results were compared with the clinicopathologic appearances. The aneuploidy rate of the leukoplakias was 17/50 (34%), and the mean DNA index (DI) of the aneuploid lesions was 1.22, with a range from 0.70 to 1.84. The incidence of the aneuploidy was significantly ( P
ISSN:0901-5027
1399-0020
DOI:10.1016/S0901-5027(05)80855-0