Insulin-related growth factor binding protein-1 levels in ovum donation pregnancies

The finding that endometrial maturation may be delayed following hormone replacement therapy has suggested that a generalised endometrial dysfunction may exist in ovum recipients. In order to investigate this suggestion further, circulating levels of IGFBP-1 were measured in samples taken throughout...

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Veröffentlicht in:European journal of obstetrics & gynecology and reproductive biology 1995-03, Vol.59 (1), p.91-94
Hauptverfasser: Brooks, A.A., Johnson, M.R., Hills, F., Chard, T., Irvine, R., Abdalla, H.I.
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Sprache:eng
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Zusammenfassung:The finding that endometrial maturation may be delayed following hormone replacement therapy has suggested that a generalised endometrial dysfunction may exist in ovum recipients. In order to investigate this suggestion further, circulating levels of IGFBP-1 were measured in samples taken throughout pregnancies conceived either spontaneously or following ovum donation. When analysed at two-weekly intervals, the serum levels of IGFBP-1 in ovum donation pregnancies failed to show the expected peak towards the end of the first trimester and were significantly reduced at week ten (U = 364.5, p = 0.0002) and twelve (U = 138.0, p = 0.0047). For the remainder of pregnancy, circulating IGFBP-1 levels were similar in both groups. The birth weight of children born to the ovum donation group was not significantly different from a normal control group, suggesting that circulating levels of IGFBP-1 in early pregnancy do not reflect local function and that IGFBP-1 does not have an essential function (in relation to birth weight) in early pregnancy.
ISSN:0301-2115
1872-7654
DOI:10.1016/0028-2243(94)02014-6