Pharmacokinetics and Metabolism of Bisoprolol-14C in Three Animal Species and in Humans

The pharmacokinetic properties of bisoprolol-C were studied in Wistar rats, beagle dogs, and Cynomolgus monkeys. Bisoprolol is well absorbed in these species; independent of the route of administration (i.v. or p.o.), 70-90% of the C-dose was recovered in urine. Faecal excretion was ~20% in rats and

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of cardiovascular pharmacology 1986, Vol.8 Suppl 11, p.S21-S28
Hauptverfasser:	Bühring, K U, Sailer, H, Faro, H.-P, Leopold, G, Pabst, J, Garbe, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Adrenergic beta-Antagonists - blood Adrenergic beta-Antagonists - metabolism Adrenergic beta-Antagonists - urine Animals Bile - metabolism Bisoprolol Blood Proteins - metabolism Blood-Brain Barrier Carbon Radioisotopes Dogs Feces - metabolism Humans Kinetics Macaca fascicularis Milk - metabolism Osmolar Concentration Placenta - metabolism Propanolamines - blood Propanolamines - metabolism Propanolamines - urine Rats Rats, Inbred Strains Tissue Distribution
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Beschreibung
Zusammenfassung:	The pharmacokinetic properties of bisoprolol-C were studied in Wistar rats, beagle dogs, and Cynomolgus monkeys. Bisoprolol is well absorbed in these species; independent of the route of administration (i.v. or p.o.), 70-90% of the C-dose was recovered in urine. Faecal excretion was ~20% in rats and
ISSN:	0160-2446 1533-4023