Bis(acetato)amminedichloro(cyclohexylamine)platinum(IV), an Orally Active Anticancer Drug

The structure of the anticancer drug bis(acetato)-amminedichloro(cyclohexylamine)platinum(IV), [PtCl2-(C2H3O2)2(C6H13N)(NH3)], is reported. The acetato groups are axial to the square plane composed of the chlorine and amine substituents. The cyclohexane ring may sterically hinder one of the acetato...

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Veröffentlicht in:	Acta crystallographica. Section C, Crystal structure communications Crystal structure communications, 1995-05, Vol.51 (5), p.822-824
Hauptverfasser:	Neidle, S., Snook, C. F., Murrer, B. A., Barnard, C. F. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemistry Biological and medical sciences Chemical Phenomena Chemistry, Physical Chlorides - chemistry Condensed matter: structure, mechanical and thermal properties Crystallization Crystallography, X-Ray Exact sciences and technology General aspects Hydrogen Bonding Inorganic compounds Medical sciences Metal complexes Molecular Conformation Molecular Structure Organoplatinum Compounds - chemistry Pharmacology. Drug treatments Physics Structure of solids and liquids crystallography Structure of specific crystalline solids
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Zusammenfassung:	The structure of the anticancer drug bis(acetato)-amminedichloro(cyclohexylamine)platinum(IV), [PtCl2-(C2H3O2)2(C6H13N)(NH3)], is reported. The acetato groups are axial to the square plane composed of the chlorine and amine substituents. The cyclohexane ring may sterically hinder one of the acetato groups for metabolic attack. The amine groups are hydrogen bonded to the carbonyl O atoms of the acetato groups.
ISSN:	0108-2701 1600-5759
DOI:	10.1107/S0108270194013600