Structure and function of the pentraxins

Over the past two years, the three-dimensional structure of the serum amyloid P component was defined by X-ray diffraction, the first such visualization of a pentraxin. Binding sites for calcium, ligands and complement were identified. New fusion proteins with amino acid sequence homology to the pen...

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Veröffentlicht in:	Current opinion in immunology 1995-02, Vol.7 (1), p.54-64
Hauptverfasser:	Gewurz, Henry, Zhang, Xiao-Hui, Lint, Thomas Franklin
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Amino Acid Sequence Animals C-Reactive Protein - chemistry C-Reactive Protein - metabolism C-Reactive Protein - physiology Complement System Proteins - metabolism Humans Lung Diseases - metabolism Lupus Erythematosus, Systemic - metabolism Molecular Sequence Data Phylogeny Serum Amyloid A Protein - chemistry Serum Amyloid A Protein - metabolism Serum Amyloid A Protein - physiology
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Beschreibung
Zusammenfassung:	Over the past two years, the three-dimensional structure of the serum amyloid P component was defined by X-ray diffraction, the first such visualization of a pentraxin. Binding sites for calcium, ligands and complement were identified. New fusion proteins with amino acid sequence homology to the pentraxins were described, and new insights were gained into pentraxin phylogeny, biosynthesis, ligands, complement activation, leukocyte reactivity and biological functions in vivo.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/0952-7915(95)80029-8