Influence of Different Doses of Methyl Ethyl Ketone on 2, 5-Hexanedione Concentrations in the Sciatic Nerve, Serum, and Urine of Rats
Rats were injected subcutaneously with 2, 5-hexanedione (2, 5-HD 2.6 m mol/kg) alone (HD group) or with 2, 5-HD and methyl ethyl ketone (MEK) (2.6 m mol/kg of each agent, HD&MEK group) or with 2, 5-HD 2.6 m mol/kg and 5 times that dose (13.0 m mol/kg) of MEK (HD&5MEK group). The concentratio...
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| Veröffentlicht in: | SANGYO EISEIGAKU ZASSHI 1995, Vol.37(1), pp.19-24,A3 |
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| container_title | SANGYO EISEIGAKU ZASSHI |
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| creator | YASUI, Takato ZHAO, Wenyuan MISUMI, Junichi AOKI, Kazuo SHIMAOKA, Akira KUDO, Masanobu |
| description | Rats were injected subcutaneously with 2, 5-hexanedione (2, 5-HD 2.6 m mol/kg) alone (HD group) or with 2, 5-HD and methyl ethyl ketone (MEK) (2.6 m mol/kg of each agent, HD&MEK group) or with 2, 5-HD 2.6 m mol/kg and 5 times that dose (13.0 m mol/kg) of MEK (HD&5MEK group). The concentration of 2, 5-HD in serum and in the sciatic nerve was determined 0.5, 1, 2, 4, 8, and 16 h after administration. Urinary 2, 5-HD concentration was determined from the beginning of administration up to 16 h afterward. 1) The concentration of 2, 5-HD in the serum, the sciatic nerve, and the urine was increased significantly (p |
| doi_str_mv | 10.1539/sangyoeisei.37.19 |
| format | Article |
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The concentration of 2, 5-HD in serum and in the sciatic nerve was determined 0.5, 1, 2, 4, 8, and 16 h after administration. Urinary 2, 5-HD concentration was determined from the beginning of administration up to 16 h afterward. 1) The concentration of 2, 5-HD in the serum, the sciatic nerve, and the urine was increased significantly (p<0.05) in the co-administered groups; the higher the MEK doses were, the greater was the increase. 2) The clearance of 2, 5-HD from both the serum and the sciatic nerve was delayed in the coadministered groups. The highest concentration in serum and the sciatic nerve appeared at 1 and 2 h respectively. After administration, the biological half-life (t1/2) of 2, 5-HD from 1 to 8 h in serum was 6.5, 5.8 and 12.0 h for the HD, HD&MEK, and HD&5 MEK groups respectively. From 8 to 16 h, the t1/2 in serum was 1.2, 3.2 and 16.6 h for the HD, HD&MEK, and HD&5MEK groups, respectively. In nerve tissue, the prolongation of clearance in the coadministered groups was greater than that in serum, the t1/2 from 2 to 8 h being 5.2, 9.6 and 19.9 h for the HD, HD&MEK, and HD&5MEK groups, respectively. From 8 to 16 h the t1/2 was 1.0, 3.0 and 16.1 h for the HD, HD&MEK, and HD&5MEK groups, respectively. 3) The average ratios of the 2, 5-HD concentration in the serum/2, 5-HD concentration in the nerve were not significantly different among the three groups (6.2, 5.4, and 6.3 for the HD, HD&MEK and HD&5MEK groups, respectively).]]></description><identifier>ISSN: 1341-0725</identifier><identifier>EISSN: 1349-533X</identifier><identifier>DOI: 10.1539/sangyoeisei.37.19</identifier><identifier>PMID: 7780859</identifier><language>eng</language><publisher>Japan: Japan Society for Occupational Health</publisher><subject>2,5-hexanedione ; Animals ; Butanones - administration & dosage ; Clearance ; Co-administration ; Delay ; Glycols - analysis ; Glycols - blood ; Glycols - urine ; Half-Life ; Male ; Methyl ethyl ketone ; Nerve ; Rats ; Rats, Wistar ; Sciatic Nerve - chemistry ; Serum ; Urine</subject><ispartof>SANGYO EISEIGAKU ZASSHI, 1995, Vol.37(1), pp.19-24,A3</ispartof><rights>Japan Society for Occupational Health</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3959-4133b7682a4cb1f2250813446aa9eaffa6e97ccd038eff83adaace8ef6e7c983</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7780859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YASUI, Takato</creatorcontrib><creatorcontrib>ZHAO, Wenyuan</creatorcontrib><creatorcontrib>MISUMI, Junichi</creatorcontrib><creatorcontrib>AOKI, Kazuo</creatorcontrib><creatorcontrib>SHIMAOKA, Akira</creatorcontrib><creatorcontrib>KUDO, Masanobu</creatorcontrib><title>Influence of Different Doses of Methyl Ethyl Ketone on 2, 5-Hexanedione Concentrations in the Sciatic Nerve, Serum, and Urine of Rats</title><title>SANGYO EISEIGAKU ZASSHI</title><addtitle>SanEiShi</addtitle><description><![CDATA[Rats were injected subcutaneously with 2, 5-hexanedione (2, 5-HD 2.6 m mol/kg) alone (HD group) or with 2, 5-HD and methyl ethyl ketone (MEK) (2.6 m mol/kg of each agent, HD&MEK group) or with 2, 5-HD 2.6 m mol/kg and 5 times that dose (13.0 m mol/kg) of MEK (HD&5MEK group). The concentration of 2, 5-HD in serum and in the sciatic nerve was determined 0.5, 1, 2, 4, 8, and 16 h after administration. Urinary 2, 5-HD concentration was determined from the beginning of administration up to 16 h afterward. 1) The concentration of 2, 5-HD in the serum, the sciatic nerve, and the urine was increased significantly (p<0.05) in the co-administered groups; the higher the MEK doses were, the greater was the increase. 2) The clearance of 2, 5-HD from both the serum and the sciatic nerve was delayed in the coadministered groups. The highest concentration in serum and the sciatic nerve appeared at 1 and 2 h respectively. After administration, the biological half-life (t1/2) of 2, 5-HD from 1 to 8 h in serum was 6.5, 5.8 and 12.0 h for the HD, HD&MEK, and HD&5 MEK groups respectively. From 8 to 16 h, the t1/2 in serum was 1.2, 3.2 and 16.6 h for the HD, HD&MEK, and HD&5MEK groups, respectively. In nerve tissue, the prolongation of clearance in the coadministered groups was greater than that in serum, the t1/2 from 2 to 8 h being 5.2, 9.6 and 19.9 h for the HD, HD&MEK, and HD&5MEK groups, respectively. From 8 to 16 h the t1/2 was 1.0, 3.0 and 16.1 h for the HD, HD&MEK, and HD&5MEK groups, respectively. 3) The average ratios of the 2, 5-HD concentration in the serum/2, 5-HD concentration in the nerve were not significantly different among the three groups (6.2, 5.4, and 6.3 for the HD, HD&MEK and HD&5MEK groups, respectively).]]></description><subject>2,5-hexanedione</subject><subject>Animals</subject><subject>Butanones - administration & dosage</subject><subject>Clearance</subject><subject>Co-administration</subject><subject>Delay</subject><subject>Glycols - analysis</subject><subject>Glycols - blood</subject><subject>Glycols - urine</subject><subject>Half-Life</subject><subject>Male</subject><subject>Methyl ethyl ketone</subject><subject>Nerve</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sciatic Nerve - chemistry</subject><subject>Serum</subject><subject>Urine</subject><issn>1341-0725</issn><issn>1349-533X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNUMtOHDEQtCIQQYQPyCGST5x2lvF4Zj0-huWp8JACkXKzej1t1mjWJrYnYj-A_8b70IpLu7uquqwuQr6zcswaLk8juOelRxvRjrkYM_mFHDJey6Lh_O_eumdFKarmKzmO0c7KshVS5vmAHAjRlm0jD8n7jTP9gE4j9YaeW2MwoEv03EeMK-gO03zZ04t1_YXJu6x0tBrRprjGN3DY2RU29dnDpQApj5FaR9Mc6aO2GdD0HsN_HNFHDMNiRMF19E-wbv3nb0jxG9k30Ec83r5H5Ony4ml6Xdw-XN1Mf94WmstGFjXjfCYmbQW1njFTVU3Z5ivrCYBEMAYmKIXWXclbNKbl0AFozP0EhZYtPyInG9vX4P8NGJNa2Kix7_MVfohKCF5Voq6zkG2EOvgYAxr1GuwCwlKxUq3CV5_CV1woJvPOj635MFtgt9vYRp35sw3_EhM8446HkAPqUb34OZOyWbttCpM7Us8hKHT8AxGynBw</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>YASUI, Takato</creator><creator>ZHAO, Wenyuan</creator><creator>MISUMI, Junichi</creator><creator>AOKI, Kazuo</creator><creator>SHIMAOKA, Akira</creator><creator>KUDO, Masanobu</creator><general>Japan Society for Occupational Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Influence of Different Doses of Methyl Ethyl Ketone on 2, 5-Hexanedione Concentrations in the Sciatic Nerve, Serum, and Urine of Rats</title><author>YASUI, Takato ; ZHAO, Wenyuan ; MISUMI, Junichi ; AOKI, Kazuo ; SHIMAOKA, Akira ; KUDO, Masanobu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3959-4133b7682a4cb1f2250813446aa9eaffa6e97ccd038eff83adaace8ef6e7c983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>2,5-hexanedione</topic><topic>Animals</topic><topic>Butanones - administration & dosage</topic><topic>Clearance</topic><topic>Co-administration</topic><topic>Delay</topic><topic>Glycols - analysis</topic><topic>Glycols - blood</topic><topic>Glycols - urine</topic><topic>Half-Life</topic><topic>Male</topic><topic>Methyl ethyl ketone</topic><topic>Nerve</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sciatic Nerve - chemistry</topic><topic>Serum</topic><topic>Urine</topic><toplevel>online_resources</toplevel><creatorcontrib>YASUI, Takato</creatorcontrib><creatorcontrib>ZHAO, Wenyuan</creatorcontrib><creatorcontrib>MISUMI, Junichi</creatorcontrib><creatorcontrib>AOKI, Kazuo</creatorcontrib><creatorcontrib>SHIMAOKA, Akira</creatorcontrib><creatorcontrib>KUDO, Masanobu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>SANGYO EISEIGAKU ZASSHI</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YASUI, Takato</au><au>ZHAO, Wenyuan</au><au>MISUMI, Junichi</au><au>AOKI, Kazuo</au><au>SHIMAOKA, Akira</au><au>KUDO, Masanobu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Different Doses of Methyl Ethyl Ketone on 2, 5-Hexanedione Concentrations in the Sciatic Nerve, Serum, and Urine of Rats</atitle><jtitle>SANGYO EISEIGAKU ZASSHI</jtitle><addtitle>SanEiShi</addtitle><date>1995</date><risdate>1995</risdate><volume>37</volume><issue>1</issue><spage>19</spage><epage>24,A3</epage><pages>19-24,A3</pages><issn>1341-0725</issn><eissn>1349-533X</eissn><abstract><![CDATA[Rats were injected subcutaneously with 2, 5-hexanedione (2, 5-HD 2.6 m mol/kg) alone (HD group) or with 2, 5-HD and methyl ethyl ketone (MEK) (2.6 m mol/kg of each agent, HD&MEK group) or with 2, 5-HD 2.6 m mol/kg and 5 times that dose (13.0 m mol/kg) of MEK (HD&5MEK group). The concentration of 2, 5-HD in serum and in the sciatic nerve was determined 0.5, 1, 2, 4, 8, and 16 h after administration. Urinary 2, 5-HD concentration was determined from the beginning of administration up to 16 h afterward. 1) The concentration of 2, 5-HD in the serum, the sciatic nerve, and the urine was increased significantly (p<0.05) in the co-administered groups; the higher the MEK doses were, the greater was the increase. 2) The clearance of 2, 5-HD from both the serum and the sciatic nerve was delayed in the coadministered groups. The highest concentration in serum and the sciatic nerve appeared at 1 and 2 h respectively. After administration, the biological half-life (t1/2) of 2, 5-HD from 1 to 8 h in serum was 6.5, 5.8 and 12.0 h for the HD, HD&MEK, and HD&5 MEK groups respectively. From 8 to 16 h, the t1/2 in serum was 1.2, 3.2 and 16.6 h for the HD, HD&MEK, and HD&5MEK groups, respectively. In nerve tissue, the prolongation of clearance in the coadministered groups was greater than that in serum, the t1/2 from 2 to 8 h being 5.2, 9.6 and 19.9 h for the HD, HD&MEK, and HD&5MEK groups, respectively. From 8 to 16 h the t1/2 was 1.0, 3.0 and 16.1 h for the HD, HD&MEK, and HD&5MEK groups, respectively. 3) The average ratios of the 2, 5-HD concentration in the serum/2, 5-HD concentration in the nerve were not significantly different among the three groups (6.2, 5.4, and 6.3 for the HD, HD&MEK and HD&5MEK groups, respectively).]]></abstract><cop>Japan</cop><pub>Japan Society for Occupational Health</pub><pmid>7780859</pmid><doi>10.1539/sangyoeisei.37.19</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1341-0725 |
| ispartof | SANGYO EISEIGAKU ZASSHI, 1995, Vol.37(1), pp.19-24,A3 |
| issn | 1341-0725 1349-533X |
| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | 2,5-hexanedione Animals Butanones - administration & dosage Clearance Co-administration Delay Glycols - analysis Glycols - blood Glycols - urine Half-Life Male Methyl ethyl ketone Nerve Rats Rats, Wistar Sciatic Nerve - chemistry Serum Urine |
| title | Influence of Different Doses of Methyl Ethyl Ketone on 2, 5-Hexanedione Concentrations in the Sciatic Nerve, Serum, and Urine of Rats |
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