Influence of Different Doses of Methyl Ethyl Ketone on 2, 5-Hexanedione Concentrations in the Sciatic Nerve, Serum, and Urine of Rats

Rats were injected subcutaneously with 2, 5-hexanedione (2, 5-HD 2.6 m mol/kg) alone (HD group) or with 2, 5-HD and methyl ethyl ketone (MEK) (2.6 m mol/kg of each agent, HD&MEK group) or with 2, 5-HD 2.6 m mol/kg and 5 times that dose (13.0 m mol/kg) of MEK (HD&5MEK group). The concentration of 2, 5-HD in serum and in the sciatic nerve was determined 0.5, 1, 2, 4, 8, and 16 h after administration. Urinary 2, 5-HD concentration was determined from the beginning of administration up to 16 h afterward. 1) The concentration of 2, 5-HD in the serum, the sciatic nerve, and the urine was increased significantly (p