Structures of folding intermediates

Structures of folding intermediates

The past year has yielded important results in the study of protein-folding intermediates. It has been shown that the equilibrium molten globule has a native-like tertiary fold and is separated from the unfolded state by a first-order phase transition. New equilibrium intermediates have been reveale...

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Veröffentlicht in:Current opinion in structural biology 1995-02, Vol.5 (1), p.74-78
1. Verfasser: Ptitsyn, Oleg B.
Format: Artikel
Sprache:eng
Schlagworte:
Protein Folding
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Beschreibung
Zusammenfassung:The past year has yielded important results in the study of protein-folding intermediates. It has been shown that the equilibrium molten globule has a native-like tertiary fold and is separated from the unfolded state by a first-order phase transition. New equilibrium intermediates have been revealed and substantial progress has been made in the understanding of two main barriers in protein folding.
ISSN:0959-440X
1879-033X
DOI:10.1016/0959-440X(95)80011-O