A physical map encompassing GP2B, EPB3, D17S183, D17S78, D17S1183, and D17S1184

The q21 region of chromosome 17 contains the gene BRCA1, which is involved in familial early-onset breast and ovarian cancers. A physical map of a region that extends from a distal boundary of the BRCA1 region, D17S78, to GP2B has been constructed. The map consists of 30 STSs, including 2 new short...

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Veröffentlicht in:	Genomics 1995, Vol.25 (1), p.295-299
Hauptverfasser:	Miki, Y., Swensen, J.J., Hobbs, M.R., Dehoff, B.S., Rosteck, P.R., Skolnick, M.H., Neuhausen, S.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences BIOLOGICAL MARKERS BIOLOGY AND MEDICINE, BASIC STUDIES BRCA1 Protein Breast Neoplasms - genetics Chromosome Mapping Chromosomes, Artificial, Yeast Chromosomes, Human, Pair 17 Cloning, Molecular CONTIGS COSMIDS DNA Primers DNA-CLONING Fundamental and applied biological sciences. Psychology GENES Genes. Genome GENETIC MAPPING Genetic Markers HEREDITARY DISEASES HUMAN CHROMOSOME 17 Humans MAMMARY GLANDS Molecular and cellular biology Molecular genetics Molecular Sequence Data Neoplasm Proteins - genetics NEOPLASMS OVARIES PLASMIDS POLYMERASE CHAIN REACTION Transcription Factors - genetics YEASTS
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Zusammenfassung:	The q21 region of chromosome 17 contains the gene BRCA1, which is involved in familial early-onset breast and ovarian cancers. A physical map of a region that extends from a distal boundary of the BRCA1 region, D17S78, to GP2B has been constructed. The map consists of 30 STSs, including 2 new short tandem repeat polymorphic markers. The contig is composed of a mixture of 7 YACs, 5 P1 plasmids, and 14 cosmids and was ordered by STS-content mapping.
ISSN:	0888-7543 1089-8646
DOI:	10.1016/0888-7543(95)80141-8