Quantitative Liquid Chromatographic Thermospray-Tandem Mass Spectrometric Analysis of Some Analgesics and Tranquilizers of the Methadone, Butyrophenone, or Diphenylbutylpiperidine Groups in Whole Blood
The results of a liquid chromatographic-mass spectrometric method for the quantitative determination of some medicaments of the methadone, butyrophenone, or diphenylbutylpiperidine groups in whole blood are presented. The method includes an extraction procedure with Bond Elut columns. The liquid chr...
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| Veröffentlicht in: | Journal of analytical toxicology 1995-03, Vol.19 (2), p.65-68 |
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| container_end_page | 68 |
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| container_issue | 2 |
| container_start_page | 65 |
| container_title | Journal of analytical toxicology |
| container_volume | 19 |
| creator | Verweij, Anthonie M.A. Hordijk, Maarten L. Lipman, Peter J.L. |
| description | The results of a liquid chromatographic-mass spectrometric method for the quantitative determination of some medicaments of the methadone, butyrophenone, or diphenylbutylpiperidine groups in whole blood are presented. The method includes an extraction procedure with Bond Elut columns. The liquid chromatograph is connected to a mass spectrometer by a thermospray interface, and to obtain as high a sensitivity and selectivity as possible, a selected reaction monitoring mass spectrometric technique in the daughter ion mode is applied. |
| doi_str_mv | 10.1093/jat/19.2.65 |
| format | Article |
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The method includes an extraction procedure with Bond Elut columns. The liquid chromatograph is connected to a mass spectrometer by a thermospray interface, and to obtain as high a sensitivity and selectivity as possible, a selected reaction monitoring mass spectrometric technique in the daughter ion mode is applied.</description><identifier>ISSN: 0146-4760</identifier><identifier>EISSN: 1945-2403</identifier><identifier>DOI: 10.1093/jat/19.2.65</identifier><identifier>PMID: 7769788</identifier><identifier>CODEN: JATOD3</identifier><language>eng</language><publisher>Niles, IL: Oxford University Press</publisher><subject>Analgesics - blood ; Analysis ; Antipsychotic Agents - blood ; Biological and medical sciences ; Butyrophenones ; Chromatography, High Pressure Liquid ; General pharmacology ; Humans ; Mass Spectrometry ; Medical sciences ; Methadone - analogs & derivatives ; Methadone - blood ; Pharmacology. 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The method includes an extraction procedure with Bond Elut columns. The liquid chromatograph is connected to a mass spectrometer by a thermospray interface, and to obtain as high a sensitivity and selectivity as possible, a selected reaction monitoring mass spectrometric technique in the daughter ion mode is applied.</description><subject>Analgesics - blood</subject><subject>Analysis</subject><subject>Antipsychotic Agents - blood</subject><subject>Biological and medical sciences</subject><subject>Butyrophenones</subject><subject>Chromatography, High Pressure Liquid</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Mass Spectrometry</subject><subject>Medical sciences</subject><subject>Methadone - analogs & derivatives</subject><subject>Methadone - blood</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Piperidines - blood</topic><topic>Tranquilizing Agents - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verweij, Anthonie M.A.</creatorcontrib><creatorcontrib>Hordijk, Maarten L.</creatorcontrib><creatorcontrib>Lipman, Peter J.L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of analytical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verweij, Anthonie M.A.</au><au>Hordijk, Maarten L.</au><au>Lipman, Peter J.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative Liquid Chromatographic Thermospray-Tandem Mass Spectrometric Analysis of Some Analgesics and Tranquilizers of the Methadone, Butyrophenone, or Diphenylbutylpiperidine Groups in Whole Blood</atitle><jtitle>Journal of analytical toxicology</jtitle><addtitle>Journal of Analytical Toxicology</addtitle><date>1995-03-01</date><risdate>1995</risdate><volume>19</volume><issue>2</issue><spage>65</spage><epage>68</epage><pages>65-68</pages><issn>0146-4760</issn><eissn>1945-2403</eissn><coden>JATOD3</coden><abstract>The results of a liquid chromatographic-mass spectrometric method for the quantitative determination of some medicaments of the methadone, butyrophenone, or diphenylbutylpiperidine groups in whole blood are presented. The method includes an extraction procedure with Bond Elut columns. The liquid chromatograph is connected to a mass spectrometer by a thermospray interface, and to obtain as high a sensitivity and selectivity as possible, a selected reaction monitoring mass spectrometric technique in the daughter ion mode is applied.</abstract><cop>Niles, IL</cop><pub>Oxford University Press</pub><pmid>7769788</pmid><doi>10.1093/jat/19.2.65</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-4760 |
| ispartof | Journal of analytical toxicology, 1995-03, Vol.19 (2), p.65-68 |
| issn | 0146-4760 1945-2403 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77309685 |
| source | MEDLINE; Oxford Journals A-Z Collection; Alma/SFX Local Collection |
| subjects | Analgesics - blood Analysis Antipsychotic Agents - blood Biological and medical sciences Butyrophenones Chromatography, High Pressure Liquid General pharmacology Humans Mass Spectrometry Medical sciences Methadone - analogs & derivatives Methadone - blood Pharmacology. Drug treatments Piperidines - blood Tranquilizing Agents - blood |
| title | Quantitative Liquid Chromatographic Thermospray-Tandem Mass Spectrometric Analysis of Some Analgesics and Tranquilizers of the Methadone, Butyrophenone, or Diphenylbutylpiperidine Groups in Whole Blood |
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