Quantitative Liquid Chromatographic Thermospray-Tandem Mass Spectrometric Analysis of Some Analgesics and Tranquilizers of the Methadone, Butyrophenone, or Diphenylbutylpiperidine Groups in Whole Blood

The results of a liquid chromatographic-mass spectrometric method for the quantitative determination of some medicaments of the methadone, butyrophenone, or diphenylbutylpiperidine groups in whole blood are presented. The method includes an extraction procedure with Bond Elut columns. The liquid chromatograph is connected to a mass spectrometer by a thermospray interface, and to obtain as high a sensitivity and selectivity as possible, a selected reaction monitoring mass spectrometric technique in the daughter ion mode is applied.