Biological Activities of Sarcosine1-Angiotensin I in Man

In order to examine whether substrate specificity of angiotensin-converting enzyme (ACE) exists or not for N-terminal substituted angiotensin I (ANG I) in man, biological activities of sarcosine1-angiotensin I (Sar1-ANG I) and the effects of an ACE inhibitor, captopril, on the Sar1-ANG I activities...

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Veröffentlicht in:	Endocrinologia Japonica 1986, Vol.33(5), pp.583-588
Hauptverfasser:	KONO, TSUYOSHI, TANIGUCHI, ATARU, IMURA, HIROO, OSEKO, FUMIMARO, KHOSLA, MAHESH C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aldosterone - blood Angiotensin I - administration & dosage Angiotensin I - analogs & derivatives Angiotensin I - metabolism Angiotensin I - physiology Angiotensin-Converting Enzyme Inhibitors Apud cells. Peptide and protein hormones. Growth factors Biological and medical sciences Blood Pressure Captopril - administration & dosage Captopril - pharmacology Fundamental and applied biological sciences. Psychology Humans Infusions, Intravenous Male Peptidyl-Dipeptidase A - physiology Renin - blood Substrate Specificity Vertebrates: endocrinology
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Zusammenfassung:	In order to examine whether substrate specificity of angiotensin-converting enzyme (ACE) exists or not for N-terminal substituted angiotensin I (ANG I) in man, biological activities of sarcosine1-angiotensin I (Sar1-ANG I) and the effects of an ACE inhibitor, captopril, on the Sar1-ANG I activities were studied in 5 normal men. The following 3 experiments were done at 1 week intervals.(1) Sarcosine1-angiotensin II (Sar1-ANG II) was infused iv at a rate of 5 pmol/kg·min from 0900 h to 0930 h in 5 normal men in a recumbent position. Blood pressure rose remarkably and the average increment was 38/31 mmHg at 30 min (p
ISSN:	0013-7219 2185-6370
DOI:	10.1507/endocrj1954.33.583