Signal Transduction by the Phosphatidylinositol Cycle in Myocardium

H. W. De Jonge, H. A. A. Van Heugten and J. M. J. Lamers. Signal Transduction by the Phosphatidylinositol Cycle in Myocardium. Journal of Molecular and Cellular Cardiology (1995) 27, 93-106. Diverse and distinct hormonal stimuli arriving at the cardiomyocyte engage specific surface receptors to init...

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Veröffentlicht in:Journal of molecular and cellular cardiology 1995, Vol.27 (1), p.93-106
Hauptverfasser: De Jonge, Henriette W., Van Heugten, Han A.A., Lamers, Jos M.J.
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Sprache:eng
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Zusammenfassung:H. W. De Jonge, H. A. A. Van Heugten and J. M. J. Lamers. Signal Transduction by the Phosphatidylinositol Cycle in Myocardium. Journal of Molecular and Cellular Cardiology (1995) 27, 93-106. Diverse and distinct hormonal stimuli arriving at the cardiomyocyte engage specific surface receptors to initiate hydrolysis of inositol phospholipids by phospholipase C whereby information flows from changes in intracellular levels of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate, 1,2-diacylglycerol and Ca 2+ to the specific phosphorylation of cellular proteins by various protein kinases such as the protein kinase C family, Ca 2+-calmodulin-dependent kinase and mitogen activated kinases. The phosphorylation products are potential regulators of the inotropic and chronotropic state, hypertrophic growth and specific gene expression and ischemic preconditioning of the myocardium. This review summarizes the current state of knowledge concerning the phosphatidylinositol cycle and its potential role in mediating various functional responses in myocardium. The multiplicity of receptor types, G-proteins, phospholipases C and protein kinases raises fundamental questions about the mechanisms that assure the precision and timing of the myocardial response to hormonal stimuli.
ISSN:0022-2828
1095-8584
DOI:10.1016/S0022-2828(08)80010-7