Sensitivity and specificity of an HIV antibody assay

Sensitivity and specificity of an HIV antibody assay

We have evaluated a new enzyme immunoassay (EIA) to measure IgG antibodies (Abs) to HIV in patients with AIDS, AIDS-related complex (ARC), AIDS contacts (AC), and low risk controls. Twenty-nine (94%) of 31 AIDS, 27 (96%) of 26 ARC, 12 (54%) of 22 AC, and 1 (2%) of 60 control patients were anti-HIV A...

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Veröffentlicht in:AIDS research 1986, Vol.2 (4), p.369-375
Hauptverfasser: CHASE, R. A, KESSLER, H. A, LANDAY, A. L, VAHEY, A, BLAAUW, B, CHUDWIN, D, DAWSON, G, HELLER, J, FALK, L
Format: Artikel
Sprache:eng
Schlagworte:
AIDS/HIV
Antibodies, Viral - analysis
Biological and medical sciences
Evaluation Studies as Topic
HIV - immunology
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunoenzyme Techniques
Immunopathology
Medical sciences
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Zusammenfassung:We have evaluated a new enzyme immunoassay (EIA) to measure IgG antibodies (Abs) to HIV in patients with AIDS, AIDS-related complex (ARC), AIDS contacts (AC), and low risk controls. Twenty-nine (94%) of 31 AIDS, 27 (96%) of 26 ARC, 12 (54%) of 22 AC, and 1 (2%) of 60 control patients were anti-HIV Ab positive by this assay. Positive results were confirmed by Western blot analysis. The EIA for anti-HIV evaluated in this study is sensitive and specific in identifying individuals who have been infected by this retrovirus.
ISSN:0737-6006
2332-4112
DOI:10.1089/aid.1.1986.2.369