Smooth muscle contracting lipid-soluble principles in chromatographic fractions of Ocimum gratissimum

Smooth muscle contracting lipid-soluble principles in chromatographic fractions of Ocimum gratissimum

Fractions isolated from Ocimum gratissimum leaves by lipid extraction and column- and thin-layer chromatography have been shown to contain components which contract guinea pig ileum, rat colon and raise rat mean arterial blood pressure. TLC analysis indicates that these compounds are fairly polar. A...

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Veröffentlicht in:Journal of ethnopharmacology 1986-10, Vol.18 (1), p.3-11
1. Verfasser: Onajobi, Funmilayo D.
Format: Artikel
Sprache:eng
Schlagworte:
Africa, Western
Animals
Biological and medical sciences
Blood Pressure - drug effects
chemical constituents of plants
Chromatography, Thin Layer
Cognitive problems, arts and sciences, folk traditions, folklore
Colon - drug effects
contraction
Ethnobotanics. Ethnoecology
Ethnology
General pharmacology
Guinea Pigs
Ileum - drug effects
In Vitro Techniques
Mass Spectrometry
Medical sciences
Miscellaneous
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Ocimum gratissimum
Pharmacognosy. Homeopathy. Health food
pharmacology
Pharmacology. Drug treatments
Plant Extracts - analysis
Plant Extracts - pharmacology
Plants, Medicinal - analysis
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Rats
Rats, Inbred Strains
smooth muscle
Traditional sciences and medicine
Tropical medicine
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Zusammenfassung:Fractions isolated from Ocimum gratissimum leaves by lipid extraction and column- and thin-layer chromatography have been shown to contain components which contract guinea pig ileum, rat colon and raise rat mean arterial blood pressure. TLC analysis indicates that these compounds are fairly polar. Analysis of one of the components by mass spectra shows the presence of an unknown with a molecular mass of at least 353 daltons containing carbon, hydrogen, oxygen and possibly nitrogen. A tentative molecular formula, as deduced from computer analysis, is either C 21H 37O 4 or C 19H 35N 3O 3.
ISSN:0378-8741
1872-7573
DOI:10.1016/0378-8741(86)90038-3