CHEMO-SENSITIVE DIFFERENCES OF PRIMARY, METASTATIC AND RECURRENT TUMORS OF HUMAN COLORECTAL CANCER

Tumor lines xenografts in nude mice used in this study include COK-1 and COK-7. COK-1(PT, LN and RE) has been established from the primary (PT), lymph node metastatic (LN) and local recurrent (RE) tumors of human colon cancer, and COK-7 (PT and LiM) has been established from the primary (PT) and liver metastatic (LiM) tumors of human rectal cancer. These tumor lines were used for the study of chemotherapeutic responses to such anti-cancer drugs as 5-FU, MMC, CPM and CDDP. Chemotherapeutic responses to these drugs in each tumor line were as follows.; COK-1 (PT) responded to only MMC, while COK-1 (RE) responded to both MMC and CDDP. However, COK-1 (LN) did not respond to any drug studied. In case of COK-7 (PT) it did not respond to any drug as well, though COK-7 (LiM) showed a response to MMC. These results indicate that each tumor line of COK-1 and COK-7 has chemosensitive differences in primary, metastatic and recurrent tumor lines.