PD 124, 895 AND PD 124, 966, TWO NEW ANTITUMOR ANTIBIOTICS

The isolation and characterization of the title antibiotics, which are produced by the same Streptomyces sp., is described. The potent antitumor agent, PD 124, 895, is an analog of hydroxyelactocin (PD 114, 721). PD 124, 966 is a new member of the depsipeptide family of antibiotics.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 1986, Vol.39(12), pp.1651-1656
Hauptverfasser:	HURLEY, T. R., BUNGE, R. H., WILLMER, N. E., HOKANSON, G. C., FRENCH, J. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Biological and medical sciences Chemical Phenomena Chemistry Chemotherapy Fatty Acids, Unsaturated - isolation & purification Fatty Acids, Unsaturated - pharmacology Magnetic Resonance Spectroscopy Medical sciences Mice Peptides - isolation & purification Peptides - pharmacology Peptides, Cyclic Pharmacology. Drug treatments Streptomyces - metabolism
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Beschreibung
Zusammenfassung:	The isolation and characterization of the title antibiotics, which are produced by the same Streptomyces sp., is described. The potent antitumor agent, PD 124, 895, is an analog of hydroxyelactocin (PD 114, 721). PD 124, 966 is a new member of the depsipeptide family of antibiotics.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.39.1651