NOVEL POLYETHER ANTIBIOTICS X-14873A, G AND H PRODUCED BY A STREPTOMYCES: TAXONOMY OF THE PRODUCING CULTURE, FERMENTATION, BIOLOGICAL AND IONOPHOROUS PROPERTIES OF THE ANTIBIOTICS

Novel polyether antibiotics X-14873A, X-14873G, and X-14873H are produced by the fermentation of Streptomyces sp. X-14873 (ATCC 31679). This report presents taxonomic studies and fermentation conditions for the antibiotic producing culture. The antibiotics are mainly active against Gram-positive bac...

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Veröffentlicht in:	Journal of antibiotics 1986, Vol.39(12), pp.1712-1718
Hauptverfasser:	LIU, CHAO-MIN, WESTLEY, JOHN W., HERMANN, T. E., PROSSER, B. LA T., PALLERONI, N., EVANS, R. H., MILLER, P. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Antibiotics Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Bacteria - drug effects Biological and medical sciences Biotechnology Fermentation Fundamental and applied biological sciences. Psychology Furans - metabolism Furans - pharmacology General aspects Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Ionophores - pharmacology Microbiology Production of active biomolecules Rumen - metabolism Streptomyces - classification Streptomyces - metabolism Structure-Activity Relationship
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Zusammenfassung:	Novel polyether antibiotics X-14873A, X-14873G, and X-14873H are produced by the fermentation of Streptomyces sp. X-14873 (ATCC 31679). This report presents taxonomic studies and fermentation conditions for the antibiotic producing culture. The antibiotics are mainly active against Gram-positive bacteria. The ionophore properties of X-14873A are also characterized.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.39.1712