Caffeine demethylation measured by breath analysis in experimental liver injury in the rat

To assess the effects of experimental liver injury on caffeine metabolism, 1 μCi/kg b.w. of [3-methyl 14C]-caffeine (together with 5 mg/kg b.w. of the cold compound) was injected i.p. to four different experimental groups and respective controls of unanesthetized male Sprague-Dawley rats. Exhaled 14...

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Veröffentlicht in:	Journal of hepatology 1995, Vol.22 (1), p.82-87
Hauptverfasser:	Schaad, Heinz J., Renner, Eberhard L., Wietholtz, Hubertus, Arnaud, Maurice J., Preisig, Rudolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile duct ligation Biological and medical sciences Breath analysis Breath Tests Caffeine - metabolism Caffeine - pharmacokinetics Caffeine demethylation Carbon Dioxide Carbon Radioisotopes Gastroenterology. Liver. Pancreas. Abdomen Hepatectomy Liver disease models Liver Diseases - metabolism Liver function Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Methylation Other diseases. Semiology Portocaval anastomosis Rat Rats Rats, Sprague-Dawley Respiration
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Zusammenfassung:	To assess the effects of experimental liver injury on caffeine metabolism, 1 μCi/kg b.w. of [3-methyl 14C]-caffeine (together with 5 mg/kg b.w. of the cold compound) was injected i.p. to four different experimental groups and respective controls of unanesthetized male Sprague-Dawley rats. Exhaled 14CO 2 was completely collected during 4 h and peak exhalation rate and fraction of dose recovered were calculated. 1 3 hepatectomy affected 14CO 2 exhalation to a limited extent, decreasing solely peak exhalation rate ( p
ISSN:	0168-8278 1600-0641
DOI:	10.1016/0168-8278(95)80264-9