Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450
Rat liver microsomal cytochrome P-450 catalyzes the NADPH dependent metabolism of arachidonic acid to six regioisomeric cis,trans-dienols. The 12(R)-hydroxyeicosatetraenoic acid is generated with a high degree of enantioselectivity while the remaining regioisomers are produced as nearly racemic mixt...
Gespeichert in:
| Veröffentlicht in: | Biochemical and biophysical research communications 1986-12, Vol.141 (3), p.1007-1011 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1011 |
|---|---|
| container_issue | 3 |
| container_start_page | 1007 |
| container_title | Biochemical and biophysical research communications |
| container_volume | 141 |
| creator | Capdevila, Jorge Yadagiri, Pendri Manna, Sukumar Falck, J.R. |
| description | Rat liver microsomal cytochrome P-450 catalyzes the NADPH dependent metabolism of arachidonic acid to six regioisomeric
cis,trans-dienols. The 12(R)-hydroxyeicosatetraenoic acid is generated with a high degree of enantioselectivity while the remaining regioisomers are produced as nearly racemic mixtures. |
| doi_str_mv | 10.1016/S0006-291X(86)80144-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77270647</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006291X86801449</els_id><sourcerecordid>77270647</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-b7a8d4ad92a26bc10737fd3b92cd9dd6a09d99f3095051996690b7f4b0b8f7ff3</originalsourceid><addsrcrecordid>eNqFkc1u1DAUhS0EKkPhESp5gVC7CFwnjh2vUFUNFKkSSBSJneXfGaMkLrZTkVfhacl0otmyuov7nXOvzkHogsB7AoR9-A4ArKoF-XnZsasOCKWVeIY2BARUNQH6HG1OyEv0KudfAIRQJs7QWXOw4HyD_l7rHPupOGzi6MNuSqqEOOLocdk7vJ9tin9mF0zMqriSlBtjMFiZYDO-vN3eb_MV9jENzmI7pTDusFFF9XNZqEW5c-PJUCVl9sHGcTXAesZDMCnmOKgem7lEs09xcPhbRVt4jV541Wf3Zp3n6Men7f3NbXX39fOXm-u7ylBKSqW56ixVVtSqZtoQ4A33ttGiNlZYyxQIK4RvQLTQEiEYE6C5pxp057n3zTl6d_R9SPH35HKRQ8jG9b0aXZyy5LzmwChfwPYIHl7OyXn5kMKg0iwJyEOg8qkTeQhcdkw-dSLFortYD0x6yemkWktY9m_XvcpG9T6p0YR8wnhbd5zCgn08Ym4J4zG4JLMJbjTOhuRMkTaG_zzyD0XOq-A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77270647</pqid></control><display><type>article</type><title>Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Capdevila, Jorge ; Yadagiri, Pendri ; Manna, Sukumar ; Falck, J.R.</creator><creatorcontrib>Capdevila, Jorge ; Yadagiri, Pendri ; Manna, Sukumar ; Falck, J.R.</creatorcontrib><description>Rat liver microsomal cytochrome P-450 catalyzes the NADPH dependent metabolism of arachidonic acid to six regioisomeric
cis,trans-dienols. The 12(R)-hydroxyeicosatetraenoic acid is generated with a high degree of enantioselectivity while the remaining regioisomers are produced as nearly racemic mixtures.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/S0006-291X(86)80144-9</identifier><identifier>PMID: 3101677</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Applied sciences ; Arachidonic Acid ; Arachidonic Acids - metabolism ; Chromatography, High Pressure Liquid ; Cytochrome P-450 Enzyme System - metabolism ; Exact sciences and technology ; Hydroxyeicosatetraenoic Acids - isolation & purification ; Hydroxyeicosatetraenoic Acids - metabolism ; Hydroxylation ; Male ; Microsomes, Liver - enzymology ; Molecular Conformation ; NADP - pharmacology ; Other techniques and industries ; Rats ; Rats, Inbred Strains</subject><ispartof>Biochemical and biophysical research communications, 1986-12, Vol.141 (3), p.1007-1011</ispartof><rights>1986 Academic Press, Inc.</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-b7a8d4ad92a26bc10737fd3b92cd9dd6a09d99f3095051996690b7f4b0b8f7ff3</citedby><cites>FETCH-LOGICAL-c441t-b7a8d4ad92a26bc10737fd3b92cd9dd6a09d99f3095051996690b7f4b0b8f7ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-291X(86)80144-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7528740$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3101677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Capdevila, Jorge</creatorcontrib><creatorcontrib>Yadagiri, Pendri</creatorcontrib><creatorcontrib>Manna, Sukumar</creatorcontrib><creatorcontrib>Falck, J.R.</creatorcontrib><title>Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Rat liver microsomal cytochrome P-450 catalyzes the NADPH dependent metabolism of arachidonic acid to six regioisomeric
cis,trans-dienols. The 12(R)-hydroxyeicosatetraenoic acid is generated with a high degree of enantioselectivity while the remaining regioisomers are produced as nearly racemic mixtures.</description><subject>Animals</subject><subject>Applied sciences</subject><subject>Arachidonic Acid</subject><subject>Arachidonic Acids - metabolism</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>Exact sciences and technology</subject><subject>Hydroxyeicosatetraenoic Acids - isolation & purification</subject><subject>Hydroxyeicosatetraenoic Acids - metabolism</subject><subject>Hydroxylation</subject><subject>Male</subject><subject>Microsomes, Liver - enzymology</subject><subject>Molecular Conformation</subject><subject>NADP - pharmacology</subject><subject>Other techniques and industries</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EKkPhESp5gVC7CFwnjh2vUFUNFKkSSBSJneXfGaMkLrZTkVfhacl0otmyuov7nXOvzkHogsB7AoR9-A4ArKoF-XnZsasOCKWVeIY2BARUNQH6HG1OyEv0KudfAIRQJs7QWXOw4HyD_l7rHPupOGzi6MNuSqqEOOLocdk7vJ9tin9mF0zMqriSlBtjMFiZYDO-vN3eb_MV9jENzmI7pTDusFFF9XNZqEW5c-PJUCVl9sHGcTXAesZDMCnmOKgem7lEs09xcPhbRVt4jV541Wf3Zp3n6Men7f3NbXX39fOXm-u7ylBKSqW56ixVVtSqZtoQ4A33ttGiNlZYyxQIK4RvQLTQEiEYE6C5pxp057n3zTl6d_R9SPH35HKRQ8jG9b0aXZyy5LzmwChfwPYIHl7OyXn5kMKg0iwJyEOg8qkTeQhcdkw-dSLFortYD0x6yemkWktY9m_XvcpG9T6p0YR8wnhbd5zCgn08Ym4J4zG4JLMJbjTOhuRMkTaG_zzyD0XOq-A</recordid><startdate>19861230</startdate><enddate>19861230</enddate><creator>Capdevila, Jorge</creator><creator>Yadagiri, Pendri</creator><creator>Manna, Sukumar</creator><creator>Falck, J.R.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19861230</creationdate><title>Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450</title><author>Capdevila, Jorge ; Yadagiri, Pendri ; Manna, Sukumar ; Falck, J.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-b7a8d4ad92a26bc10737fd3b92cd9dd6a09d99f3095051996690b7f4b0b8f7ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Applied sciences</topic><topic>Arachidonic Acid</topic><topic>Arachidonic Acids - metabolism</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>Exact sciences and technology</topic><topic>Hydroxyeicosatetraenoic Acids - isolation & purification</topic><topic>Hydroxyeicosatetraenoic Acids - metabolism</topic><topic>Hydroxylation</topic><topic>Male</topic><topic>Microsomes, Liver - enzymology</topic><topic>Molecular Conformation</topic><topic>NADP - pharmacology</topic><topic>Other techniques and industries</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Capdevila, Jorge</creatorcontrib><creatorcontrib>Yadagiri, Pendri</creatorcontrib><creatorcontrib>Manna, Sukumar</creatorcontrib><creatorcontrib>Falck, J.R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Capdevila, Jorge</au><au>Yadagiri, Pendri</au><au>Manna, Sukumar</au><au>Falck, J.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1986-12-30</date><risdate>1986</risdate><volume>141</volume><issue>3</issue><spage>1007</spage><epage>1011</epage><pages>1007-1011</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>Rat liver microsomal cytochrome P-450 catalyzes the NADPH dependent metabolism of arachidonic acid to six regioisomeric
cis,trans-dienols. The 12(R)-hydroxyeicosatetraenoic acid is generated with a high degree of enantioselectivity while the remaining regioisomers are produced as nearly racemic mixtures.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>3101677</pmid><doi>10.1016/S0006-291X(86)80144-9</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 1986-12, Vol.141 (3), p.1007-1011 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77270647 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Applied sciences Arachidonic Acid Arachidonic Acids - metabolism Chromatography, High Pressure Liquid Cytochrome P-450 Enzyme System - metabolism Exact sciences and technology Hydroxyeicosatetraenoic Acids - isolation & purification Hydroxyeicosatetraenoic Acids - metabolism Hydroxylation Male Microsomes, Liver - enzymology Molecular Conformation NADP - pharmacology Other techniques and industries Rats Rats, Inbred Strains |
| title | Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T07%3A41%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Absolute%20configuration%20of%20the%20hydroxyeicosatetraenoic%20acids%20(HETEs)%20formed%20during%20catalytic%20oxygenation%20of%20arachidonic%20acid%20by%20microsomal%20cytochrome%20P-450&rft.jtitle=Biochemical%20and%20biophysical%20research%20communications&rft.au=Capdevila,%20Jorge&rft.date=1986-12-30&rft.volume=141&rft.issue=3&rft.spage=1007&rft.epage=1011&rft.pages=1007-1011&rft.issn=0006-291X&rft.eissn=1090-2104&rft.coden=BBRCA9&rft_id=info:doi/10.1016/S0006-291X(86)80144-9&rft_dat=%3Cproquest_cross%3E77270647%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77270647&rft_id=info:pmid/3101677&rft_els_id=S0006291X86801449&rfr_iscdi=true |