Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450

Rat liver microsomal cytochrome P-450 catalyzes the NADPH dependent metabolism of arachidonic acid to six regioisomeric cis,trans-dienols. The 12(R)-hydroxyeicosatetraenoic acid is generated with a high degree of enantioselectivity while the remaining regioisomers are produced as nearly racemic mixt...

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Veröffentlicht in:	Biochemical and biophysical research communications 1986-12, Vol.141 (3), p.1007-1011
Hauptverfasser:	Capdevila, Jorge, Yadagiri, Pendri, Manna, Sukumar, Falck, J.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied sciences Arachidonic Acid Arachidonic Acids - metabolism Chromatography, High Pressure Liquid Cytochrome P-450 Enzyme System - metabolism Exact sciences and technology Hydroxyeicosatetraenoic Acids - isolation & purification Hydroxyeicosatetraenoic Acids - metabolism Hydroxylation Male Microsomes, Liver - enzymology Molecular Conformation NADP - pharmacology Other techniques and industries Rats Rats, Inbred Strains
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Zusammenfassung:	Rat liver microsomal cytochrome P-450 catalyzes the NADPH dependent metabolism of arachidonic acid to six regioisomeric cis,trans-dienols. The 12(R)-hydroxyeicosatetraenoic acid is generated with a high degree of enantioselectivity while the remaining regioisomers are produced as nearly racemic mixtures.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/S0006-291X(86)80144-9