Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex

We tested the hypothesis that blockade of glutamatergic receptors in the parabrachial nucleus (PBN) of chloralose-anesthetized cats attenuated the reflex airway dilation evoked by activation of pulmonary stretch receptors. Unilateral microinjection of kynurenic acid (50 nl, 100 mM) into the PBN reve...

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Veröffentlicht in:	Brain research 1995-02, Vol.671 (2), p.314-316
Hauptverfasser:	Motekaitis, Ann M., Solomon, Irene C., Kaufman, Marc P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway smooth muscle Animals Autonomic nervous system Biological and medical sciences Cats Fundamental and applied biological sciences. Psychology Kynurenic Acid - administration & dosage Kynurenic Acid - pharmacology Microinjections Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Pneumotaxic center Pons - drug effects Pons - physiology Pulmonary Stretch Receptors - drug effects Pulmonary Stretch Receptors - physiology Reflex - drug effects Reflex - physiology Respiratory Mechanics - physiology Vertebrates: nervous system and sense organs
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Zusammenfassung:	We tested the hypothesis that blockade of glutamatergic receptors in the parabrachial nucleus (PBN) of chloralose-anesthetized cats attenuated the reflex airway dilation evoked by activation of pulmonary stretch receptors. Unilateral microinjection of kynurenic acid (50 nl, 100 mM) into the PBN reversibly attenuated the reflex relaxation of the trachealis muscle in 7 cats. These findings suggest that the PBN is part of the central pathway mediating the airway dilation component of the Hering-Breuer reflex.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(94)01371-N