Nuclear lipid peroxidation induced in rat liver by T-2 mycotoxin

N. Ahmed and G. C. Ram. Nuclear lipid peroxidation induced in rat liver by T-2 mycotoxin. Toxicon 24, 947 – 949, 1986.—Oral administration to rats of T-2 mycotoxin (1.25 mg/kg) for five days causes an increase in lipid peroxidation (ascorbate-induced as well as NADPH-dependent) in hepatic nuclei, wh...

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Veröffentlicht in:	Toxicon (Oxford) 1986, Vol.24 (9), p.947-949
Hauptverfasser:	Ahmed, Nizamuddin, Ram, G.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Nucleus - metabolism food contamination Fusarium Glutathione Transferase - antagonists & inhibitors lipid peroxidation Lipid Peroxides - biosynthesis liver Liver - drug effects Liver - metabolism Male Medical sciences mycotoxins Plant poisons toxicology Rats Sesquiterpenes - pharmacology T-2 Toxin - pharmacology Toxicology
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Zusammenfassung:	N. Ahmed and G. C. Ram. Nuclear lipid peroxidation induced in rat liver by T-2 mycotoxin. Toxicon 24, 947 – 949, 1986.—Oral administration to rats of T-2 mycotoxin (1.25 mg/kg) for five days causes an increase in lipid peroxidation (ascorbate-induced as well as NADPH-dependent) in hepatic nuclei, while the activity of liver glutathione- S-transferase (EC 2.5.1.18) is decreased. The hepatotoxicity could be due to lipid peroxidation induced by depletion of hepatic reduced glutathione and/or production of free radicals.
ISSN:	0041-0101 1879-3150
DOI:	10.1016/0041-0101(86)90095-4