Effects of Onpi-to (TJ-8117) on mesangial injury induced by anti Thy-1 antibody

We investigated the effect of Onpi-to (TJ-8117) on the mesangial injury induced by anti-Thy-1 antibody. TJ-8117 (400 mg/kg/day, p.o.) given from the 1st day (from the day of injection of the anti-thymocyte serum) or 4th day (after mesangial proliferation), markedly inhibited the mesangial proliferat...

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Veröffentlicht in:	Folia Pharmacologica Japonica 1995, Vol.105(2), pp.63-75
Hauptverfasser:	HATTORI, Tomohisa, SHINDO, Shoichiro, HISADA, Takamitsu, FUJITSUKA, Naoki, HIBINO, Tomoko, TERAZONO, Yoshiki, MARUNO, Masao
Format:	Artikel
Sprache:	jpn
Schlagworte:	Animals Disease Models, Animal Drugs, Chinese Herbal - therapeutic use Glomerulonephritis, Membranoproliferative - drug therapy Glomerulonephritis, Membranoproliferative - etiology Male Rats Rats, Wistar Thy-1 Antigens
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Zusammenfassung:	We investigated the effect of Onpi-to (TJ-8117) on the mesangial injury induced by anti-Thy-1 antibody. TJ-8117 (400 mg/kg/day, p.o.) given from the 1st day (from the day of injection of the anti-thymocyte serum) or 4th day (after mesangial proliferation), markedly inhibited the mesangial proliferation and hypercellularity in glomeruli. TJ-8117 prevented the increase in the number of PCNA or ED-1 positive cells in glomeruli. These results suggest that TJ-8117 is effective against glomerular disease with mesangial injury.
ISSN:	0015-5691 1347-8397
DOI:	10.1254/fpj.105.63