Regional distribution of high-affinity [ 3H]somatostatin binding sites in the human brain

The distribution of high-affinity binding sites for [ 3H]somatostatin has been studied in membrane preparations from a number of regions of normal human brain. The highest densities of binding sites (> 48 fmol/mg protein) were found in the cerebral and cerebellar cortices and the hippocampus, wit...

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Veröffentlicht in:	Brain research 1986-11, Vol.398 (1), p.141-147
Hauptverfasser:	Whitford, Carol A., Bloxham, Clive A., Snell, Christopher R., Candy, John M., Hirst, Barry H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Binding site Binding Sites Binding, Competitive Biological and medical sciences Brain - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebellar Cortex - metabolism Cerebral Cortex - metabolism Female Fundamental and applied biological sciences. Psychology High affinity Human brain Humans Male Middle Aged Radioligand Assay Rats Receptors, Neurotransmitter - metabolism Receptors, Somatostatin Somatostatin Tritium Vertebrates: nervous system and sense organs
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Zusammenfassung:	The distribution of high-affinity binding sites for [ 3H]somatostatin has been studied in membrane preparations from a number of regions of normal human brain. The highest densities of binding sites (> 48 fmol/mg protein) were found in the cerebral and cerebellar cortices and the hippocampus, with intermediate binding densities (30–46 fmol/mg protein) being present in the basal ganglia, amygdala, septum and claustrum. The lowest densities of binding sites (
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(86)91259-X