Electrophilic 18F from a siemens 11 MeV proton-only cyclotron

Electrophilic 18F from a siemens 11 MeV proton-only cyclotron

Because more and more PET centres are using small proton cyclotrons there is a renewed interest in methods for the production of electrophilic 18F by proton irradiation of [ 18O]O 2. A method for the routine production of clinically useful quantities of [ 18F]F 2 having a specific activity of 35 Ci/...

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Veröffentlicht in:Nuclear medicine and biology 1995, Vol.22 (1), p.111-116
Hauptverfasser: Chirakal, R., Adams, R.M., Firnau, G., Schrobilgen, G.J., Coates, G., Garnett, E.S.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Contrast media. Radiopharmaceuticals
Cyclotrons
Fluorine Radioisotopes
Medical sciences
Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:Because more and more PET centres are using small proton cyclotrons there is a renewed interest in methods for the production of electrophilic 18F by proton irradiation of [ 18O]O 2. A method for the routine production of clinically useful quantities of [ 18F]F 2 having a specific activity of 35 Ci/mmol has been developed and implemented using an 11 MeV proton cyclotron and [ 18O]O 2. Based on the yield, purity, reproducibility, and specific activity of [ 18F]F 2 this is the most efficient method reported thus far.
ISSN:0969-8051
1872-9614
DOI:10.1016/0969-8051(94)E0064-P