The formation of peroxynitrite in vivo from nitric oxide and superoxide

Peroxynitrite is predicted to be formed in vivo from the reaction of nitric oxide and superoxide. Nitric oxide at concentrations as low as 3 nM is expected to compete efficiently for Superoxide near the surface of endothelial cells, based on competition kinetics.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemico-biological interactions 1995-05, Vol.96 (2), p.203-206
Hauptverfasser:	Squadrito, Giuseppe L., Pryor, William A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell metabolism, cell oxidation Cell physiology Endothelium Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Free radicals Fundamental and applied biological sciences. Psychology Kinetics Molecular and cellular biology Nitrates - metabolism Nitric oxide Nitric Oxide - metabolism Peroxynitrite Reaction Superoxide Superoxides - metabolism
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Beschreibung
Zusammenfassung:	Peroxynitrite is predicted to be formed in vivo from the reaction of nitric oxide and superoxide. Nitric oxide at concentrations as low as 3 nM is expected to compete efficiently for Superoxide near the surface of endothelial cells, based on competition kinetics.
ISSN:	0009-2797 1872-7786
DOI:	10.1016/0009-2797(94)03591-U