Functions of the Proteasome: The Lysis at the End of the Tunnel

Most proteins in eukaryotic cells are degraded by a soluble, adenosine triphosphate (ATP)-dependent pathway present in both the nucleus and cytosol. This non-lysosomal pathway is discussed.

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Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1995-04, Vol.268 (5210), p.522-523
1. Verfasser:	Goldberg, Alfred L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antigens Archaeal Proteins Bacteria Binding Sites Biochemistry Biological and medical sciences Cell regulation Cells Cellular control mechanisms Crystallography, X-Ray Cysteine Endopeptidases - chemistry Cysteine Endopeptidases - metabolism Endopeptidases - chemistry Endopeptidases - metabolism Enzymes Fundamental and applied biological sciences. Psychology Humans Hydrolysis Immune system Molecular and cellular biology Molecular genetics Molecules Multienzyme Complexes - chemistry Multienzyme Complexes - metabolism Nucleophiles Perspectives Physiological aspects Proteases Proteasome Endopeptidase Complex Proteins Proteins - metabolism Thermoplasma - enzymology Thermoplasma acidophilum Translation. Translation factors. Protein processing Ubiquitins Ubiquitins - metabolism
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Beschreibung
Zusammenfassung:	Most proteins in eukaryotic cells are degraded by a soluble, adenosine triphosphate (ATP)-dependent pathway present in both the nucleus and cytosol. This non-lysosomal pathway is discussed.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.7725095