Effects of SMS 201-995 on intermediary metabolism and endocrine status in normal and diabetic humans

The hormonal and metabolic effects of the somatostatin analogue SMS 201-995 have been examined in normal and diabetic humans. When 50 μg of analogue was administered subcutaneously at 8 A.M. and 5:30 P.M., growth hormone secretion over 24 hours was not significantly affected, and the nocturnal growt...

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Veröffentlicht in:	The American journal of medicine 1986-12, Vol.81 (6), p.88-93
Hauptverfasser:	Johnston, Desmond G., Davies, Robert R., Alberti, K.George M.M., Miller, Margaret, Turner, Steven J., Watson, Malcolm, Orskov, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Glucose - metabolism Circadian Rhythm - drug effects Diabetes Mellitus - metabolism Growth Hormone - metabolism Humans Insulin - metabolism Male Octreotide Somatostatin - analogs & derivatives Somatostatin - pharmacology Thyrotropin - metabolism
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Zusammenfassung:	The hormonal and metabolic effects of the somatostatin analogue SMS 201-995 have been examined in normal and diabetic humans. When 50 μg of analogue was administered subcutaneously at 8 A.M. and 5:30 P.M., growth hormone secretion over 24 hours was not significantly affected, and the nocturnal growth hormone surge persisted in normal subjects and in type II diabetic patients. Insulin secretion was suppressed in both groups, but glucose tolerance deteriorated only in the normal subjects. Gastrointestinal side effects developed in both groups. Subcutaneous administration of 50 μg of SMS 201-995 at 11 P.M. decreased nocturnal growth hormone secretion (peak, 5 ± 2 milliunits/liter versus 23 ± 6 milliunits/liter; p
ISSN:	0002-9343 1555-7162
DOI:	10.1016/0002-9343(86)90589-9