Cutaneous mastocytosis complicating pregnancy

Background: Telangiectasia macularis eruptiva perstans, a rare form of cutaneous mastocytosis associated with elevated histamine excretion, has not previously been reported to complicate pregnancy. Case: A woman presented in the late second trimester with an anaphylactoid reaction, rash, uterine contractions, and vaginal bleeding. Skin biopsy revealed perivascular mast-cell infiltration. Her urinary histamine excretion was markedly elevated. She was treated successfully with tocolytics and antihistamines. Conclusion: Elevated histamine excretion in biopsyproven cutaneous mastocytosis may be associated with preterm labor.